ArticleNetwork neuroscience (Cambridge, Mass.)2019
Network remodeling induced by transcranial brain stimulation: A computational model of tDCS-triggered cell assembly formation.
Article in Network neuroscience (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Lasting effects of transcranial direct current stimulation on the inducibility of synaptic plasticity by paired-associative stimulation in humans.Journal of neuroengineering and rehabilitation · 2024Trial
- Two-year outcomes of epicranial focal cortex stimulation in pharmacoresistant focal epilepsy.Epilepsia · 2025Article
- Article
- Resolving inconsistent effects of tDCS on learning using a homeostatic structural plasticity model.Frontiers in network physiology · 2025Article
- Synaptic reorganization of synchronized neuronal networks with synaptic weight and structural plasticity.PLoS computational biology · 2024Article
- Effectiveness assessment of repetitive transcranial alternating current stimulation with concurrent EEG and fNIRS measurement.Health information science and systems · 2023Article
- Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks.PLoS computational biology · 2023Article
- A microfluidic perspective on conventional in vitro transcranial direct current stimulation methods.Journal of neuroscience methods · 2023Review
- Mathematical Model Insights into EEG Origin under Transcranial Direct Current Stimulation (tDCS) in the Context of Psychosis.Journal of clinical medicine · 2022Article
- Homeostatic control of synaptic rewiring in recurrent networks induces the formation of stable memory engrams.PLoS computational biology · 2022Article
- Excitatory-inhibitory balance modulates the formation and dynamics of neuronal assemblies in cortical networks.Science advances · 2021Article
- Memories in a network with excitatory and inhibitory plasticity are encoded in the spiking irregularity.PLoS computational biology · 2021Article
- Frontoparietal anodal tDCS reduces ketamine-induced oscillopathies.Translational neuroscience · 2021Article
- Electrophysiological Effects of Transcranial Direct Current Stimulation on Neural Activity in the Rat Motor Cortex.Frontiers in neuroscience · 2020Article
- Editorial: Linking experimental and computational connectomics.Network neuroscience (Cambridge, Mass.) · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcranial direct current stimulation (tDCS) is a variant of noninvasive neuromodulation, which promises treatment for brain diseases like major depressive disorder. In experiments, long-lasting aftereffects were observed, suggesting that persistent plastic changes are induced. The mechanism underlying the emergence of lasting aftereffects, however, remains elusive. Here we propose a model, which assumes that tDCS triggers a homeostatic response of the network involving growth and decay of synapses. The cortical tissue exposed to tDCS is conceived as a recurrent network of excitatory and inhibitory neurons, with synapses subject to homeostatically regulated structural plasticity. We systematically tested various aspects of stimulation, including electrode size and montage, as well as stimulation intensity and duration. Our results suggest that transcranial stimulation perturbs the homeostatic equilibrium and leads to a pronounced growth response of the network. The stimulated population eventually eliminates excitatory synapses with the unstimulated population, and new synapses among stimulated neurons are grown to form a cell assembly. Strong focal stimulation tends to enhance the connectivity within new cell assemblies, and repetitive stimulation with well-chosen duty cycles can increase the impact of stimulation even further. One long-term goal of our work is to help in optimizing the use of tDCS in clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.