ArticleLaryngoscope investigative otolaryngology2019
A structured histopathology-based analysis of surgical outcomes in chronic rhinosinusitis with and without nasal polyps.
Article in Laryngoscope investigative otolaryngology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 19 citations in OpenAlex.
- Chronic rhinosinusitis with nasal polyps: Key considerations in the multidisciplinary team approach.Clinical and translational allergy · 2025Review
- Outcomes of biological therapy in patients with severe asthma with chronic rhinosinusitis in Saudi Arabia: patients with nasal polyps versus those without nasal polyps.BMC pulmonary medicine · 2024Observational
- Characterization of epithelial cells, connective tissue cells and immune cells in human upper airway mucosa by immunofluorescence multichannel image cytometry: a pilot study.Histochemistry and cell biology · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesStructured histopathology reporting has been recently described for detailing immunopathological characteristics of chronic rhinosinusitis (CRS), and can be utilized for subtyping CRS and personalizing management. This study scrutinized elements of structured histopathology to identify characteristics that prognosticate outcomes following endoscopic sinus surgery (ESS) for CRS patients with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP).
methodsOutcomes following ESS were measured using the patient-reported 22-item sinonasal outcome test (SNOT-22). Changes in total SNOT-22 scores at 6 and 12 months postoperatively were analyzed. Thirteen parameters reported in structured histopathology of sinus surgical tissue were studied for association with outcomes postsurgery. The overall cohort of all CRS patients was studied, along with subgroup analyses of CRSwNP and CRSsNP patients.
resultsIn the entire CRS cohort (n = 171), eosinophil count >10 per high power field (HPF) was associated with greater improvement in SNOT-22 scores at 6 months post-ESS (
conclusionsAt 6 months post-ESS, tissue eosinophilia is associated with significantly higher improvement in SNOT-22 scores, but this difference is diluted by 12 months. Fibrosis was associated with less favorable outcomes in SNOT-22 scores for CRSwNP patients at 12 months and may be a prognosticator for poorer long-term outcomes. LEVEL OF EVIDENCE: 4.
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