Evidence map›Paper›PMID 31637258›Full record

ArticleBioMed research international2019

CRISPR/Cas9 Knockout of Bak Mediates Bax Translocation to Mitochondria in response to TNF

Jingtian Zhang, Han Niu, Zhizhuang Joe Zhao, Xueqi Fu, Yuxiang Wang, Xu Zhang, Fuqiang Zhang, Linlin Zeng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jingtian ZhangEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Han NiuEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Zhizhuang Joe ZhaoEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Xueqi FuEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Yuxiang WangEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Xu ZhangEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.
Fuqiang ZhangScientific Research Centre of China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
Linlin ZengEdmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin University, Changchun, 130012, China.ORCID https://orcid.org/0000-0002-8653-9909
Jilin University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TNF

Indexed as

Apoptosisbcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinCaspasesCell Line, TumorCRISPR-Cas SystemsCycloheximideCytosolGene Expression Regulation, NeoplasticGene Knockout TechniquesHumansMitochondriaProto-Oncogene Proteins c-bcl-2RNA, Small InterferingTumor Necrosis Factor-alphabcl-2-Associated X Proteinbcl-2 Homologous Antagonist-Killer ProteinBCL2 protein, humanCaspasesCycloheximideProto-Oncogene Proteins c-bcl-2RNA, Small InterferingTumor Necrosis Factor-alpha

Identifiers

PMID31637258
PMCPMC6766168
OpenAlexW2974887893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.