Evidence map›Paper›PMID 31637195›Full record

ArticleInternational journal of ophthalmology2019

Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study.

Leonardo Mastropasqua, Silvio Di Staso, Rossella D'Aloisio, Alessandra Mastropasqua, Luca Di Antonio, Alfonso Senatore, Marco Ciancaglini, Marta Di Nicola, Giuseppe Di Martino, Daniele Tognetto and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Leonardo MastropasquaDepartment of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Silvio Di StasoDepartment of Life, Health and Environmental Sciences, Ophthalmology Clinic, University of L'Aquila, L'Aquila 67100, Italy.
Rossella D'AloisioDepartment of Medicine, Surgery and Health Sciences, Eye Clinic, University of Trieste, Trieste 34129, Italy.
Alessandra MastropasquaDepartment of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Luca Di AntonioDepartment of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Alfonso SenatoreDepartment of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Marco CiancagliniDepartment of Life, Health and Environmental Sciences, Ophthalmology Clinic, University of L'Aquila, L'Aquila 67100, Italy.
Marta Di NicolaDepartment of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Giuseppe Di MartinoDepartment of Medicine and Science of Ageing, School of Hygiene and Preventive Medicine, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
Daniele TognettoDepartment of Medicine, Surgery and Health Sciences, Eye Clinic, University of Trieste, Trieste 34129, Italy.
Lisa TotoDepartment of Medicine and Science of Ageing, Ophthalmology Clinic, University "G. d'Annunzio" Chieti-Pescara, Chieti 66100, Italy.
University of Chieti-Pescara · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the efficacy and safety of ranibizumab (RZB group) and dexamethasone implant (DEX group) intravitreal treatments in patients with treatment-naïve center involved diabetic macular edema (DME) by means of functional and morphological assessments.

methodsThis retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity (BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness (CMT) by means of structural optical coherence tomography (OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all cases.

resultsFunctional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups with a greater increase in the DEX group compared to the RBZ group (

conclusionBoth treatments are very effective for DME treatment during 6mo of follow-up with a lower retreatment rate in DEX group.

Indexed as

diabetic macular edemaintravitreal dexamethasone implantintravitreal ranibizumab injectionsoptical coherence tomography angiography

Identifiers

PMID31637195
PMCPMC6796097
OpenAlexW2974487998

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.