ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- A viscosity-tunable microgel-in-sol phase for localized inner ear delivery of small hydrophilic drug.Materials today. Bio · 2026Article
- 3D-Printed Piezoionic/Bioelectronic Hydrogel for Electro-Metabolic Regulation of Osteogenic Differentiation.Advanced healthcare materials · 2026Article
- Multifunctional composite microgels: From structural design to biomedical applications.Materials today. Bio · 2026Review
- Biomaterial Strategies for Three-Dimensional Bioprinting and Drug Delivery Application.Materials (Basel, Switzerland) · 2026Review
- Wearable Sensors Fabricated by 3D-Printed Composite Hydrogel with 2D Fillers.Small methods · 2026Review
- Granular Hydrogels as Modular Biomaterials: From Structural Design to Biological Responses.Advanced healthcare materials · 2026Review
- Advanced cell-adaptable hydrogels for bioprinting.Bioactive materials · 2025Review
- Direct laser writing of electronically conductive microstructures within soft hydrogel substrates.Materials today. Bio · 2025Article
- Printable Conductive Hydrogels and Elastomers for Biomedical Application.Gels (Basel, Switzerland) · 2025Review
- High-Throughput Mechanical Characterization of Single Microgel Particles by Fluidic Force Microscopy.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Metrics for studying the porous void space of packed particles.bioRxiv : the preprint server for biology · 2025Article
- 3D-Printable Granular Hydrogel Composed of Hyaluronic Acid-Chitosan Hybrid Polyelectrolyte Complex Microgels.Biomacromolecules · 2025Article
- Injectable ionic hydrogel conductors: Advancing material design to transform cardiac pacing.Biomaterials · 2025Article
- Design of PEG-Based Hydrogels as Soft Ionic Conductors.Journal of biomedical materials research. Part A · 2025Article
- Embedded 3D Bioprinting of Collagen Inks into Microgel Baths to Control Hydrogel Microstructure and Cell Spreading.Advanced healthcare materials · 2024Article
- Granular Biphasic Colloidal Hydrogels for 3D Bioprinting.Advanced healthcare materials · 2024Article
- Conductive Microgel Annealed Scaffolds Enhance Myogenic Potential of Myoblastic Cells.Advanced healthcare materials · 2024Article
- Wet tissue adhesive polymeric powder hydrogels for skeletal muscle regeneration.Bioactive materials · 2024Article
- Stimuli-responsive microcarriers and their application in tissue repair: A review of magnetic and electroactive microcarrier.Bioactive materials · 2024Review
- Design and characterization of electroactive gelatin methacrylate hydrogel incorporated with gold nanoparticles empowered with parahydroxybenzaldehyde and curcumin for advanced tissue engineering applications.Journal of materials science. Materials in medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conductive hydrogels are attractive to mimic electrophysiological environments of biological tissues and toward therapeutic applications. Injectable and conductive hydrogels are of particular interest for applications in 3D printing or for direct injection into tissues; however, current approaches to add conductivity to hydrogels are insufficient, leading to poor gelation, brittle properties, or insufficient conductivity. Here, an approach is developed using the jamming of microgels to form injectable granular hydrogels, where i) hydrogel microparticles (i.e., microgels) are formed with water-in-oil emulsions on microfluidics, ii) microgels are modified via an in situ metal reduction process, and iii) the microgels are jammed into a solid, permitting easy extrusion from a syringe. Due to the presence of metal nanoparticles at the jammed interface with high surface area in this unique design, the granular hydrogels have greater conductivity than non-particle (i.e., bulk) hydrogels treated similarly or granular hydrogels either without metal nanoparticles or containing encapsulated nanoparticles. The conductivity of the granular hydrogels is easily modified through mixing conductive and non-conductive microgels during fabrication and they can be applied to the 3D printing of lattices and to bridge muscle defects. The versatility of this conductive granular hydrogel will permit numerous applications where conductive materials are needed.
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Registered trials
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