Evidence map›Paper›PMID 31637157›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

Exosome-Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing.

Hyosuk Kim, Sun Young Wang, Gijung Kwak, Yoosoo Yang, Ick Chan Kwon, Sun Hwa Kim

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04849104 (Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 241 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
241citing papers in PubMed, 3 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04849104 active not recruitingnot on this mapstarted 2021, after this paper: background citation

Cohort Study of Airway Microecology and the Pathogenesis and Evolution of Chronic Obstructive Pulmonary Disease

TypeobservationalSponsorShanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong UniversityRan2021 to 2026Enrolled210ConditionsChronic Obstructive Pulmonary Disease
3 · Its place in the literature

Who cites it

241 citing papers in PubMed, 3 syntheses or guidelines pooled it, 538 citations in OpenAlex.

  1. Pooled it
  2. Role of Exosomes in Dermal Wound Healing: A Systematic Review.The Journal of investigative dermatology · 2022
    Pooled it
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181 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hyosuk KimKU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea.
Sun Young WangKU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea.
Gijung KwakKU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea.
Yoosoo YangCenter for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea.
Ick Chan KwonKU-KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea.
Sun Hwa KimCenter for Theragnosis Biomedical Research Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea.ORCID https://orcid.org/0000-0002-2076-111X
Korea University · KRKorea Institute of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages (Mϕs) critically contribute to wound healing by coordinating inflammatory, proliferative, and angiogenic processes. A proper switch from proinflammatory M1 to anti-inflammatory M2 dominant Mϕs accelerates the wound healing processes leading to favorable wound-care outcomes. Herein, an exosome-guided cell reprogramming technique is proposed to directly convert M1 to M2 Mϕs for effective wound management. The M2 Mϕ-derived exosomes (M2-Exo) induce a complete conversion of M1 to M2 Mϕs in vitro. The reprogrammed M2 Mϕs turn Arginase (M2-marker) and iNOS (M1-marker) on and off, respectively, and exhibit distinct phenotypic and functional features of M2 Mϕs. M2-Exo has not only Mϕ reprogramming factors but also various cytokines and growth factors promoting wound repair. After subcutaneous administration of M2-Exo into the wound edge, the local populations of M1 and M2 Mϕs are markedly decreased and increased, respectively, showing a successful exosome-guided switch to M2 Mϕ polarization. The direct conversion of M1 to M2 Mϕs at the wound site accelerates wound healing by enhancing angiogenesis, re-epithelialization, and collagen deposition. The Mϕ phenotype switching induced by exosomes possessing the excellent cell reprogramming capability and innate biocompatibility can be a promising therapeutic approach for various inflammation-associated disorders by regulating the balance between pro- versus anti-inflammatory Mϕs.

Indexed as

cutaneous wound healingdirect cell reprogrammingexosomesmacrophage phenotype switch

Identifiers

PMID31637157
PMCPMC6794619
OpenAlexW2970718184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.