Evidence map›Paper›PMID 31636938›Full record

ArticleEvolution letters2019

Compensatory

Brian P H Metzger, Patricia J Wittkopp

Abstract read
In one paragraph

Article in Evolution letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Chromosome-specific drift under stabilizing selection generates polygenic barriers to sex chromosome turnover.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. The regulatory architecture of gene expression variation inbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Quantitative omnigenic model discovers interpretable genome-wide associations.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Contributions of mutation and selection to regulatory variation: lessons from thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  10. Mechanisms of regulatory evolution in yeast.Current opinion in genetics & development · 2022
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian P H MetzgerDepartment of Ecology and Evolutionary Biology University of Michigan Ann Arbor Michigan 48109.
Patricia J WittkoppDepartment of Ecology and Evolutionary Biology University of Michigan Ann Arbor Michigan 48109.ORCID https://orcid.org/0000-0001-7619-0048

Funding

University of Michigan Training Program in Genomic ScienceT32HG000040 · NHGRI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sebastian Zoellner · 1995 to 2026
$16.4M
Genetic mechanisms and evolutionary processes underlying diversity within and between speciesR35GM118073 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2016 to 2025
$4.1M
Evolution of Gene Expression in YeastR01GM108826 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WITTKOPP, PATRICIA JEAN · 2013 to 2015
$865k
NHGRI NIH HHS T32 HG000040NIGMS NIH HHS R01 GM108826NIGMS NIH HHS R35 GM118073
6 · The paper itself

Abstract

Heritable variation in gene expression is common within species. Much of this variation is due to genetic differences outside of the gene with altered expression and is

Indexed as

CompensationeQTLgene regulationmappingstabilizing selection

Identifiers

PMID31636938
PMCPMC6791293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.