ArticleJournal of animal science and biotechnology2019
Aquaglyceroporins but not orthodox aquaporins are involved in the cryotolerance of pig spermatozoa.
Article in Journal of animal science and biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Recent advances in cryotolerance biomarkers for semen preservation in frozen form-A systematic review.PloS one · 2024Pooled it
- Phloretin as a functional feed bioactive in livestock: Biological role, biosynthesis, and practical applications.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Review
- Perspectives in porcine semen conservation (liquid and frozen).The Journal of reproduction and development · 2026Review
- Comparative analysis of AQP7 expression and cryotolerance in X- and Y-chromosome bearing bovine sperm.Frontiers in cell and developmental biology · 2025Article
- Role of aquaporins in corneal healing post chemical injury.Experimental eye research · 2023Review
- Molecular Markers: A New Paradigm in the Prediction of Sperm Freezability.International journal of molecular sciences · 2023Review
- Variation of existence and location of aquaporin 3 in relation to cryoresistance of ram spermatozoa.Frontiers in veterinary science · 2023Article
- Identification of protein candidates in spermatozoa of water buffalo (Frontiers in cell and developmental biology · 2023Article
- Relevance of Aquaporins for Gamete Function and Cryopreservation.Animals : an open access journal from MDPI · 2022Review
- Aquaporins and Animal Gamete Cryopreservation: Advances and Future Challenges.Animals : an open access journal from MDPI · 2022Review
- HVCN1 but Not Potassium Channels Are Related to Mammalian Sperm Cryotolerance.International journal of molecular sciences · 2021Article
- Aquaporins Are Essential to Maintain Motility and Membrane Lipid Architecture During Mammalian Sperm Capacitation.Frontiers in cell and developmental biology · 2021Article
- High Levels of Tumor Necrosis Factor-Alpha Reduce Placental Aquaporin 3 Expression and ImpairFrontiers in physiology · 2021Article
- Quantitative study of unsaturated transport of glycerol through aquaglyceroporin that has high affinity for glycerol.RSC advances · 2020Article
- Article
- Effect of AQP Inhibition on Boar Sperm Cryotolerance Depends on the Intrinsic Freezability of the Ejaculate.International journal of molecular sciences · 2019Article
- Cryotolerance of Stallion Spermatozoa Relies on Aquaglyceroporins rather than Orthodox Aquaporins.Biology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAquaporins (AQPs) are a family of transmembrane water channels that includes orthodox AQPs, aquaglyceroporins (GLPs) and superAQPs. AQP3, AQP7, AQP9 and AQP11 have been identified in boar sperm, and they are crucial for sperm maturation and osmoregulation. Water exchange is an important event in cryopreservation, which is the most efficient method for long-term storage of sperm. However, the freeze-thaw process leads to sperm damage and a loss of fertilizing potential. Assuming that the quality of frozen-thawed sperm partially depends on the regulation of osmolality variations during this process, AQPs might play a crucial role in boar semen freezability. In this context, the aim of this study was to unravel the functional relevance of the different groups of AQPs for boar sperm cryotolerance through three different inhibitors.
resultsInhibition of different groups of AQPs was found to have different effects on boar sperm cryotolerance. Whereas the use of 1,3-propanediol (PDO), an inhibitor of orthodox AQPs and GLPs, decreased total motility (
conclusionsThe effects of the different inhibitors suggest that GLPs rather than orthodox AQPs are relevant for boar sperm freezability. Moreover, the positive effect of PDO on sperm quality suggests a cryoprotective role for this molecule.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.