Evidence map›Paper›PMID 31636665›Full record

ArticleJournal of oncology2019

Yttrium-90-Labeled Anti-Glypican 3 Radioimmunotherapy Halts Tumor Growth in an Orthotopic Xenograft Model of Hepatocellular Carcinoma.

Andrew D Ludwig, Kevin P Labadie, Y David Seo, Donald K Hamlin, Holly M Nguyen, Vimukta M Mahadev, Raymond S Yeung, D S Wilbur, James O Park

Open access · hybridAbstract read
In one paragraph

Article in Journal of oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Glypican-3-targeted bioconjugates for hepatocellular carcinoma: design, engineering, and translational applications.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Glypican-3-TargetedJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  8. Article
  9. Glypican-3 targeted delivery ofScientific reports · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Andrew D LudwigDepartment of Surgery, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-6567-5031
Kevin P LabadieDepartment of Surgery, University of Washington, Seattle, WA, USA.
Y David SeoDepartment of Surgery, University of Washington, Seattle, WA, USA.
Donald K HamlinDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
Holly M NguyenDepartment of Urology, University of Washington, Seattle, WA, USA.
Vimukta M MahadevDepartment of Surgery, University of Washington, Seattle, WA, USA.
Raymond S YeungDepartment of Surgery, University of Washington, Seattle, WA, USA.ORCID https://orcid.org/0000-0001-5090-3046
D S WilburDepartment of Radiation Oncology, University of Washington, Seattle, WA, USA.
James O ParkDepartment of Surgery, University of Washington, Seattle, WA, USA.
University of Washington · US

Funding

Caliper Life Sciences IVIS Lumina II imaging systemS10OD010652 · OD · UNIVERSITY OF WASHINGTON · PI COOKSON, BRAD T · 2012 to 2012
$161k
NIH HHS S10 OD010652
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the second most lethal malignancy globally and is increasing in incidence in the United States. Unfortunately, there are few effective systemic treatment options, particularly for disseminated disease. Glypican-3 (GPC3) is a proteoglycan cell surface receptor overexpressed in most HCCs and provides a unique target for molecular therapies. We have previously demonstrated that PET imaging using a

Identifiers

PMID31636665
PMCPMC6766125
OpenAlexW2972819636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.