SynthesisNeural plasticity2019
Transcranial Magnetic Stimulation as a Potential Biomarker in Multiple Sclerosis: A Systematic Review with Recommendations for Future Research.
Synthesis in Neural plasticity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05496881 (Evaluating Task-Oriented Exercise Effects on Walking Function and the Central Nervous System in People With Multiple Sclerosis), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluating Task-Oriented Exercise Effects on Walking Function and the Central Nervous System in People With Multiple Sclerosis
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the impact of transcranial electrical stimulation (TES) on cognitive dysfunction in patients with multiple sclerosis.Neurodegenerative disease management · 2026Pooled it
- Trial
- The Heart's Electromagnetic Field in Emotions, Empathy and Human Connection: Biosensor-Derived Insights into Heart-Brain Axis Mechanisms and a Basis for Novel BioMagnetoTherapies.Sensors (Basel, Switzerland) · 2026Review
- Delayed transcallosal conduction to the lesioned sensorimotor cortex in multiple Sclerosis: A combined TMS 7 T-MRI study.NeuroImage. Clinical · 2026Article
- Gait instability is a more specific predictor of corticospinal tract function than gait speed in clinically stable multiple sclerosis.Scientific reports · 2025Article
- Cardiorespiratory fitness does not predict longitudinal changes in manual dexterity, cognition or corticospinal excitability in multiple sclerosis.Frontiers in aging neuroscience · 2025Article
- Article
- Motor function in multiple sclerosis assessed by navigated transcranial magnetic stimulation mapping.Journal of neurology · 2024Article
- Review
- MEPFeatX-automated feature extraction of motor-evoked potentials in transcranial magnetic stimulation.Frontiers in neuroscience · 2024Article
- The Cortical Silent Period and Its Association with Fatigue in Multiple Sclerosis: The Need for Standardized Data Collection.Brain sciences · 2023Article
- Task-oriented exercise effects on walking and corticospinal excitability in multiple sclerosis: protocol for a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2023Article
- Age and asymmetry of corticospinal excitability, but not cardiorespiratory fitness, predict cognitive impairments in multiple sclerosis.IBRO neuroscience reports · 2023Article
- Expression of CD40 and CD192 in Classical Monocytes in Multiple Sclerosis Patients Assessed with Transcranial Magnetic Stimulation.Biomedicines · 2023Article
- Links between Neuroanatomy and Neurophysiology with Turning Performance in People with Multiple Sclerosis.Sensors (Basel, Switzerland) · 2023Article
- Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood.Scientific reports · 2023Article
- Article
- Monitoring of the pharmacological treatment availability in patients with multiple sclerosis in the Greater Poland population.Reumatologia · 2023Review
- Evidence of Neuroplastic Changes after Transcranial Magnetic, Electric, and Deep Brain Stimulation.Brain sciences · 2022Review
- Motor evoked potentials for multiple sclerosis, a multiyear follow-up dataset.Scientific data · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system. Disease progression is variable and unpredictable, warranting the development of biomarkers of disease status. Transcranial magnetic stimulation (TMS) is a noninvasive method used to study the human motor system, which has shown potential in MS research. However, few reviews have summarized the use of TMS combined with clinical measures of MS and no work has comprehensively assessed study quality. This review explored the viability of TMS as a biomarker in studies of MS examining disease severity, cognitive impairment, motor impairment, or fatigue. Methodological quality and risk of bias were evaluated in studies meeting selection criteria. After screening 1603 records, 30 were included for review. All studies showed high risk of bias, attributed largely to issues surrounding sample size justification, experimenter blinding, and failure to account for key potential confounding variables. Central motor conduction time and motor-evoked potentials were the most commonly used TMS techniques and showed relationships with disease severity, motor impairment, and fatigue. Short-latency afferent inhibition was the only outcome related to cognitive impairment. Although there is insufficient evidence for TMS in clinical assessments of MS, this review serves as a template to inform future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.