ArticleFrontiers in genetics2019
Quantitative Trait Loci Mapping for Lameness Associated Phenotypes in Holstein-Friesian Dairy Cattle.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Profiling Detection and Classification of Lameness Methods in British Dairy Cattle Research: A Systematic Review and Meta-Analysis.Frontiers in veterinary science · 2020Pooled it
- Identification of cis-sQTL demonstrates genetic associations and functional implications of inflammatory processes in Nelore cattle muscle tissue.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Exploring the Genetic Basis of Ketosis: Preliminary GWAS Findings on Beta-Hydroxybutyrate Levels in Holstein Cattle.International journal of genomics · 2025Article
- Kompetitive Allele Specific PCR Genotyping of 89 SNPs in Romanian Spotted and Romanian Brown Cattle Breeds and Their Association with Clinical Mastitis.Animals : an open access journal from MDPI · 2023Article
- Single-step genome-wide association analyses of claw horn lesions in Holstein cattle using linear and threshold models.Genetics, selection, evolution : GSE · 2023Article
- Genetic parameters of sole lesion recovery in Holstein cows.Journal of dairy science · 2023Article
- The bovine foot skin microbiota is associated with host genotype and the development of infectious digital dermatitis lesions.Microbiome · 2023Article
- Genetic parameters and genome-wide association study of digital cushion thickness in Holstein cows.Journal of dairy science · 2022Article
- Functional Variants Associated WithFrontiers in genetics · 2022Article
- Detection of genomic regions underlying milk production traits in Valle del Belice dairy sheep using regional heritability mapping.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2021Article
- Genome-Wide Association Studies Reveal Susceptibility Loci for Noninfectious Claw Lesions in Holstein Dairy Cattle.Frontiers in genetics · 2021Article
- Genome-Wide Association Studies Reveal Susceptibility Loci for Digital Dermatitis in Holstein Cattle.Animals : an open access journal from MDPI · 2020Article
- Uncovering Sub-Structure and Genomic Profiles in Across-Countries Subpopulations of Angus Cattle.Scientific reports · 2020Article
- Signatures of Selection in Composite Vrindavani Cattle of India.Frontiers in genetics · 2020Article
- A Prospective Cohort Study on the Development of Claw Horn Disruption Lesions in Dairy Cattle; Furthering our Understanding of the Role of the Digital Cushion.Frontiers in veterinary science · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Lameness represents a significant challenge for the dairy cattle industry, resulting in economic losses and reduced animal health and welfare. The existence of underlying genomic variation for lameness associated traits has the potential to improve selection strategies by using genomic markers. Therefore, the aim of this study was to identify genomic regions and potential candidate genes associated with lameness traits. Lameness related lesions and digital cushion thickness were studied using records collected by our research team, farm records, and a combination of both. Genome-wide analyses were performed to identify significant genomic effects, and a combination of single SNP association analysis and regional heritability mapping was used to identify associated genomic regions. Significant genomic effects were identified for several lameness related traits: Two genomic regions were identified on chromosome 3 associated with digital dermatitis and interdigital hyperplasia, one genomic region on chromosome 23 associated with interdigital hyperplasia, and one genomic region on chromosome 2 associated with sole haemorrhage. Candidate genes in those regions are mainly related to immune response and fibroblast proliferation. Quantitative trait loci (QTL) identified in this study could enlighten the understanding of lameness pathogenesis, providing an opportunity to improve health and welfare in dairy cattle with the addition of these regions into selection programs.
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Registered trials
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