Evidence map›Paper›PMID 31636495›Full record

ArticleDialogues in clinical neuroscience2019

The "systems approach" to treating the brain: opportunities in developmental psychopharmacology
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Silvia Bussone, Luisa Lo Iacono

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Dialogues in clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Silvia BussoneAuthor affiliations: PhD student, Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza", Via degli Apuli, 1, 00185, Rome, Italy (Silvia Bussone); Senior researcher, IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy; Department of Psychology, University of Rome "La Sapienza", Via dei Marsi, 78, 00185, Rome, Italy (Luisa Lo Iacono). Address for correspondence: IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy. (e-mail: l.loiacono@hsantalucia.it).
Luisa Lo IaconoAuthor affiliations: PhD student, Department of Dynamic and Clinical Psychology, University of Rome "La Sapienza", Via degli Apuli, 1, 00185, Rome, Italy (Silvia Bussone); Senior researcher, IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy; Department of Psychology, University of Rome "La Sapienza", Via dei Marsi, 78, 00185, Rome, Italy (Luisa Lo Iacono). Address for correspondence: IRCCS Santa Lucia Foundation, Via del Fosso di Fiorano 64, 00143, Rome, Italy. (e-mail: l.loiacono@hsantalucia.it).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The significance of early life for the long-term programming of mental health is increasingly being recognized. However, most psychotropic medications are currently intended for adult patients, and early psychopharmacological approaches aimed at reverting aberrant neurodevelopmental trajectories are missing. Psychopharmacologic intervention at an early age faces the challenge of operating in a highly plastic system and requires a comprehensive knowledge of neurodevelopmental mechanisms. Recently the systems biology approach has contributed to the understanding of neuroplasticity mechanisms from a new perspective that interprets them as the result of complex and dynamic networks of signals from different systems. This approach is creating opportunities for developmental psychopharmacology, suggesting novel targets that can modulate the course of development by interfering with neuroplasticity at an early age. We will discuss two interconnected systems-the immune and gut microbiota-that regulate neurodevelopment and that have been implicated in preclinical research as new targets in the prevention of aberrant brain development.
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Indexed as

PsychopharmacologySystems BiologyBrainDrug DevelopmentHumansImmune SystemInterdisciplinary ResearchMental DisordersMental HealthMicrobiotaMicrogliaPsychotropic DrugsPsychotropic Drugsbrain developmentmicrobiotamicrogliapsychopharmacologysystems biologytherapeutic opportunity

Identifiers

PMID31636495
PMCPMC6787541

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.