Evidence map›Paper›PMID 31636490›Full record

ReviewDialogues in clinical neuroscience2019

Harnessing the microbiota to treat neurological diseases
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Neeraj K Surana

Open access · diamondAbstract readReview
In one paragraph

Review in Dialogues in clinical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Opportunities and challenges in psychopharmacology
.Dialogues in clinical neuroscience · 2019
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Neeraj K SuranaDepartments of Pediatrics, Molecular Genetics, Microbiology and Immunology, Duke University, Durham, North Carolina, USA.
Duke University · US

Funding

Deconstructing how the microbiota influences the mucosal innate immune systemK08AI108690 · NIAID · DUKE UNIVERSITY · PI SURANA, NEERAJ K · 2014 to 2018
$926k
NIAID NIH HHS K08 AI108690
6 · The paper itself

Abstract

Studies over the last decade have transformed our previously simplistic view of microbes, having only a pathogenic role in disease to a more robust understanding that they are critical for maintaining human health. Indeed, our microbiota-the collection of commensal organisms that live in and on each of us-contributes to nearly every facet of host physiology, from ontogeny of the immune system to neurological function to metabolism. Although the specific details of these host-microbe interactions are still being elucidated for most diseases, the coupling of clinical samples with animal models of disease have provided key insights. This review provides some general background on the microbiota, highlights a few examples of how the microbiota influences diseases of the central nervous system, and provides a perspective for how these findings may be clinically translatable.
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Indexed as

AnimalsBrainGastrointestinal MicrobiomeHumansImmune SystemNervous System DiseasesTranslational Research, Biomedicalclinical translationcommensal bacteriagut–brain axisimmunomodulationmicrobial metabolismmicrobiotaneurological disease

Identifiers

PMID31636490
PMCPMC6787539
OpenAlexW2982191240

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.