ArticleWorld journal of gastroenterology2019
Nucleoside diphosphate-linked moiety X-type motif 15 R139C genotypes impact 6-thioguanine nucleotide cut-off levels to predict thiopurine-induced leukopenia in Crohn's disease patients.
Article in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Early proactive monitoring of DNA-thioguanine in patients with Crohn's disease predicts thiopurine-induced late leucopenia in NUDT15/TPMT normal metabolizers.World journal of gastroenterology · 2024Trial
- Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report.Clinical and translational science · 2026Article
- Pediatric autoimmune hepatitis in the Asia-Pacific region: practical considerations for guideline implementation.Hepatology international · 2025Article
- Analysis of the NUDT15 gene and metabolites of azathioprine in Japanese patients with inflammatory bowel disease.BMC gastroenterology · 2023Article
- Plasma lipidomic profiling of thiopurine-induced leukopenia after NUDT15 genotype-guided dosing in Chinese IBD patients.Frontiers in nutrition · 2023Article
- A novel single-tube multiplex real-time PCR assay for genotyping of thiopurine intolerance-causing variantExperimental biology and medicine (Maywood, N.J.) · 2021Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThiopurine-induced leukopenia (TIL) is a life-threatening toxicity and occurs with a high frequency in the Asian population. Although nucleoside diphosphate-linked moiety X-type motif 15 (
aimTo determine the 6TGN cut-off levels after dividing patients into subgroups according to their
methodsPatients' clinical and epidemiological characteristics were collected from medical records from July 2014 to February 2017.
resultsA total of 411 Crohn's disease patients were included. TIL was observed in 72 individuals with a median 6TGN level of 323.4 pmol/8 × 10
conclusionThe predictive sensitivity of TIL based on 6TGN is dramatically increased after subgrouping according to
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