ArticleNature medicine2019
Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
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Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
88 citing papers in PubMed, 120 citations in OpenAlex.
- mTORC2-NaChannels (Austin, Tex.) · 2026Article
- To scramble or not: Steric blocking 2'-MOE/PS control antisense oligonucleotides across cellular models.Molecular therapy. Nucleic acids · 2026Article
- Altered neural electrophysiological properties in the anterior cingulate cortex in a mouse model of Prader-Willi syndrome.The Journal of physiology · 2026Article
- PTEN Regulates Microtubule Polymerization via mTORC2, But Not mTORC1, in Peripheral Sensory Neurons.eNeuro · 2026Article
- Parvalbumin interneuron activation rescues both seizures and impaired social novelty in digenic absence epilepsy mice.Science advances · 2026Article
- Temporal control of sgRNA library activation unlocks large-scale in vivo CRISPR screens.Cell reports methods · 2026Article
- Scaling of Neuronal Growth and Excitability Through Separable mTORC1 and mTORC2 Pathways.bioRxiv : the preprint server for biology · 2026Article
- Cell-Intrinsic Regulation of Epilepsy-Associated Pathology by mTORC1 and mTORC2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Repurposing drugs for treating the neurobehavioral manifestations of PTEN hamartoma tumor syndrome.iScience · 2026Article
- Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior.Acta pharmaceutica Sinica. B · 2026Article
- Research progress of small molecule protein kinase inhibitors (SMKIs) in the treatment of colorectal cancer: mechanism, application, and future prospects.Frontiers in pharmacology · 2026Review
- Altered PI3K/mTOR Signaling within the Forebrain Leads to Respiratory Deficits in a Mouse Model of Epilepsy.eNeuro · 2025Article
- Metabolic reprogramming in neurodegenerative diseases: New insights into mTOR-mediated microglial polarization.Journal of translational internal medicine · 2025Article
- Quantitative cytoarchitectural phenotyping of deparaffinized human brain tissues.Communications biology · 2025Article
- Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes.Molecular psychiatry · 2025Article
- Targeting mechanistic target of rapamycin complex 2 attenuates immunopathology in systemic lupus erythematosus.Rheumatology (Oxford, England) · 2025Article
- Investigating the impact of severe maternal SARS-CoV-2 infection on infant DNA methylation and neurodevelopment.Molecular psychiatry · 2025Article
- Review
- Genetic advances in neurodevelopmental disorders.Medical review (2021) · 2025Review
- Mdga2 deficiency leads to an aberrant activation of BDNF/TrkB signaling that underlies autism-relevant synaptic and behavioral changes in mice.PLoS biology · 2025Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 2 institutions in 1 country.
Chien-Ju ChenDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Martina SgrittaDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Jacqunae MaysDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Hongyi ZhouDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Rocco LuceroDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Jin ParkDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
I-Ching WangDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Jun Hyoung ParkDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Benny Abraham KaipparettuDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Loredana StoicaDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Paymaan Jafar-NejadIonis Pharmaceuticals, Carlsbad, CA, USA.
Frank RigoIonis Pharmaceuticals, Carlsbad, CA, USA.
Jeannie ChinDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Jeffrey L NoebelsDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
Mauro Costa-MattioliDepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USA. costamat@bcm.edu.ORCID http://orcid.org/0000-0002-9809-4732
Baylor College of Medicine · USIonis Pharmaceuticals (United States) · US
Funding
PLASTICITY IN DEVELOPING EPILEPTIC BRAINR01NS029709 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI NOEBELS, JEFFREY · 1991 to 2025
$9.1MThe integrated stress response in cognitive disordersR01NS076708 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI PFAFFINGER, PAUL, RAY, RUSSELL S · 2012 to 2025
$7.9MRole of deltaFosB in hippocampal gene expression and function in neurological diseaseR01NS085171 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI CHIN, JEANNIE · 2014 to 2022
$4.4MAccelerated depletion of hippocampal neural stem cells in neurological diseaseR01NS086965 · NINDS · THOMAS JEFFERSON UNIVERSITY · PI CHIN, JEANNIE · 2014 to 2018
$2.0MMechanisms of synaptic plasticity and memoryR01MH096816 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI COSTA-MATTIOLI, MAURO · 2012 to 2016
$1.9MNIMH NIH HHS R01 MH096816NINDS NIH HHS R01 NS029709NINDS NIH HHS R01 NS076708NINDS NIH HHS R01 NS085171NINDS NIH HHS R01 NS086965
Abstract
Dysregulation of the mammalian target of rapamycin (mTOR) signaling, which is mediated by two structurally and functionally distinct complexes, mTORC1 and mTORC2, has been implicated in several neurological disorders
Indexed as
AnimalsBrainDisease Models, AnimalHumansLoss of Function MutationMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2MiceMice, KnockoutNervous System DiseasesOligonucleotides, AntisensePTEN PhosphohydrolaseRapamycin-Insensitive Companion of mTOR ProteinTOR Serine-Threonine KinasesTuberous Sclerosis Complex 1 ProteinMechanistic Target of Rapamycin Complex 1Mechanistic Target of Rapamycin Complex 2mTOR protein, mouseOligonucleotides, AntisensePTEN PhosphohydrolasePTEN protein, humanPten protein, mouseRapamycin-Insensitive Companion of mTOR Proteinrictor protein, mouseTOR Serine-Threonine KinasesTsc1 protein, mouseTuberous Sclerosis Complex 1 Protein
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.