ArticleNature human behaviour2019
Genetic correlates of social stratification in Great Britain.
Article in Nature human behaviour, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 3 of them syntheses that pooled it.
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Who cites it
121 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.American journal of human genetics · 2023Pooled it
- A meta-analysis of genetic effects associated with neurodevelopmental disorders and co-occurring conditions.Nature human behaviour · 2023Pooled it
- Association Between Trp64Arg Polymorphism of Beta-3 Adrenergic Receptor Gene and Susceptibility to Overactive Bladder: A Meta-Analysis.Frontiers in genetics · 2022Pooled it
- Predicting the geographical distribution of drug use disorder in Sweden from the geographical variation in social deprivation, genetic risk and urbanization.Molecular psychiatry · 2026Article
- Determinants of functional burden pleiotropy and gene dosage responses across human traits.Nature communications · 2026Article
- Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status.Communications medicine · 2026Article
- Estimation of direct and indirect polygenic effects and gene-environment interactions using polygenic scores in case-parent trio studies.Nature genetics · 2026Article
- Evaluating confounding in rare variant genome wide association studies.Nature communications · 2026Article
- Genomic-Relatedness Matching Expands Population Coverage, Improves Power, and Reduces Bias in Genetic Association Analyses.medRxiv : the preprint server for health sciences · 2026Article
- Phenome-derived polygenic scores and social determinants jointly shape context-dependent disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Pitfalls in estimating and interpreting the contribution of ultra-rare genetic variants to the heritability of complex traits.medRxiv : the preprint server for health sciences · 2026Article
- Within- and between-family genetic effects on educational achievement vary across countries and ages.Molecular psychiatry · 2026Article
- Regional Personality Variation in Sweden: Trait Clusters, Links to Health and Well-Being, and Historical Context.Scandinavian journal of psychology · 2026Article
- A spectral component approach leveraging identity-by-descent graphs to address recent population structure in genomic analysis.Genome research · 2026Article
- Topological stratification of continuous genetic variation in large biobanks.PLoS genetics · 2026Article
- Assessing Orthogonality in Gene-Environment Interaction Studies Using Polygenic Indices.Behavior genetics · 2026Article
- Genetic effects on migration behavior contribute to increasing spatial differentiation at trait-associated loci in Estonia.iScience · 2025Article
- Genome-wide analysis of brain age identifies 59 associated loci and unveils relationships with mental and physical health.Nature aging · 2025Article
- SPC: a SPectral Component approach leveraging Identity-by-Descent graphs to address recent population structure in genomic analysis.medRxiv : the preprint server for health sciences · 2025Article
- Polygenic Scores of Executive Function Provide Limited Support for Genetic Confounding With Socio-Economic Measures.Genes, brain, and behavior · 2025Article
61 more citing papers are in PubMed but not listed here.
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Funding
Abstract
Human DNA polymorphisms vary across geographic regions, with the most commonly observed variation reflecting distant ancestry differences. Here we investigate the geographic clustering of common genetic variants that influence complex traits in a sample of ~450,000 individuals from Great Britain. Of 33 traits analysed, 21 showed significant geographic clustering at the genetic level after controlling for ancestry, probably reflecting migration driven by socioeconomic status (SES). Alleles associated with educational attainment (EA) showed the most clustering, with EA-decreasing alleles clustering in lower SES areas such as coal mining areas. Individuals who leave coal mining areas carry more EA-increasing alleles on average than those in the rest of Great Britain. The level of geographic clustering is correlated with genetic associations between complex traits and regional measures of SES, health and cultural outcomes. Our results are consistent with the hypothesis that social stratification leaves visible marks in geographic arrangements of common allele frequencies and gene-environment correlations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.