Evidence map›Paper›PMID 31636298›Full record

ArticleScientific reports2019

Loss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy.

Mi-Gi Lee, Min-Ah Choi, Sehyun Chae, Mi-Ae Kang, Hantae Jo, Jin-Myoung Baek, Kyu-Ree In, Hyein Park, Hyojin Heo, Dongmin Jang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

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  11. Zinc and Autophagy in Age-Related Macular Degeneration.International journal of molecular sciences · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 1 country.

Mi-Gi LeeDepartment of Food Science and Technology, College of Life Sciences, Kyung Hee University, Yongin, 446-701, Republic of Korea.
Min-Ah ChoiDepartment of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu, 42415, Republic of Korea.
Sehyun ChaeKorea Brain Bank, Korean Brain Research Institute, Daegu, 41062, Republic of Korea.
Mi-Ae KangDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Hantae JoDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Jin-Myoung BaekDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Kyu-Ree InDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Hyein ParkDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Hyojin HeoDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Dongmin JangDepartment of Biomedical Sciences, Major in Molecular Medicine, Ajou University Graduate School, Suwon, South Korea.
Sofia BritoDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Sung Tae KimDepartment of Pharmaceutical Engineering, Inje University, Gimhae-si, 50834, Korea.
Dae-Ok KimDepartment of Food Science and Technology, College of Life Sciences, Kyung Hee University, Yongin, 446-701, Republic of Korea.ORCID http://orcid.org/0000-0001-9262-1354
Jong-Soo LeeDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea.
Jae-Ryong KimDepartment of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu, 42415, Republic of Korea. kimjr000@gmail.com.
Bum-Ho BinDepartment of Bological Sciences, Ajou University, Suwon, 443-380, Korea. bhb@ajou.ac.kr.ORCID http://orcid.org/0000-0002-3312-702X
Ajou University · KRKyung Hee University · KRYeungnam University CollegeInje University · KRKorea Brain Research Institute · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibrosarcoma is a skin tumor that is frequently observed in humans, dogs, and cats. Despite unsightly appearance, studies on fibrosarcoma have not significantly progressed, due to a relatively mild tumor severity and a lower incidence than that of other epithelial tumors. Here, we focused on the role of a recently-found dermis zinc transporter, ZIP13, in fibrosarcoma progression. We generated two transformed cell lines from wild-type and ZIP13-KO mice-derived dermal fibroblasts by stably expressing the Simian Virus (SV) 40-T antigen. The ZIP13

Indexed as

AutophagyAnimalsAzacitidineCation Transport ProteinsCell DeathCell LineDermisDisease Models, AnimalDNA (Cytosine-5-)-MethyltransferasesDown-RegulationEthylenediaminesFibrosarcomaHumansMice, KnockoutMicrotubule-Associated ProteinsZincAzacitidineCation Transport ProteinsDNA (Cytosine-5-)-MethyltransferasesEthylenediaminesMap1lc3b protein, mouseMicrotubule-Associated ProteinsN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamineSlc39a13 protein, mouseZinc

Identifiers

PMID31636298
PMCPMC6803768
OpenAlexW2980921240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.