ArticleScientific reports2019
Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles.Nature communications · 2024Article
- Synthesis of chiral Cu(II) complexes from pro-chiral Schiff base ligand and investigation of their catalytic activity in the asymmetric synthesis of 1,2,3-triazoles.Scientific reports · 2024Article
- Kinetic Resolution of Racemic Mixtures via Enantioselective Photocatalysis.ACS applied materials & interfaces · 2021Article
- Enantioselective Nickel-Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution.Journal of the American Chemical Society · 2021Article
- Coetaneous catalytic kinetic resolution of alkynes and azides through asymmetric triazole formation.Scientific reports · 2019Article
- Phosphino-Triazole Ligands for Palladium-Catalyzed Cross-Coupling.Organometallics · 2018Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
A non-enzymatic simultaneous (coined coetaneous) kinetic resolution of a racemic alkyne and racemic azide, utilising an asymmetric CuAAC reaction is reported. The use of a CuCl (R,R)-Ph-Pybox catalyst system effects a simultaneous kinetic resolution of two racemic starting materials to give one major triazolic diastereoisomer in the ratio 74:12:4:10 (dr 84:16, 90% ee maj). The corresponding control reaction using an achiral copper catalyst gives the four possible diastereoisomers in a 23:27:23:27 ratio, demonstrating minimal inherent substrate control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.