ArticleProceedings of the National Academy of Sciences of the United States of America2019
During infant maltreatment, stress targets hippocampus, but stress with mother present targets amygdala and social behavior.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 73 citations in OpenAlex.
- The microglial TREM2 receptor programs hippocampal development in a mouse model of childhood deprivation.Brain, behavior, and immunity · 2026Article
- Different early-life adversity paradigms have disparate effects on maternal care, neuronal activation, and social behavior in developing mice.Neurobiology of stress · 2026Article
- Postpartum adversity in rats creates a hypervigilant maternal state through selective salience-circuit recruitment.Neurobiology of stress · 2026Article
- Attachment Theory: Novel Clinical and Molecular Insights.Biomolecules · 2026Review
- Social circuits under developmental threat: Bridging rodent and human neuroscience.Developmental review : DR · 2025Article
- Erratic Maternal Care Induces Avoidant-Like Attachment Deficits in a Mouse Model of Early Life Adversity.eNeuro · 2025Article
- Early adversity alters brain architecture and increases susceptibility to mental health disorders.Nature reviews. Neuroscience · 2025Review
- Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early-life adversity.Alcohol, clinical & experimental research · 2025Article
- Early positive tactile stimulation reverses the increase of anxiety and decrease of sociality induced by early chronic mechanical pain in mandarin voles.Integrative zoology · 2025Article
- A sensitive period for the development of episodic-like memory in mice.Current biology : CB · 2025Article
- Building a social brain: Cells, circuits and behavior across the lifespan.Neurobiology of stress · 2025Review
- Female rats exposed to early life scarcity-adversity are resilient to later life changes in maternal behavior.Hormones and behavior · 2025Article
- Sex-Specific Outcomes in a Rat Model of Early-Life Stress Due to Adverse Caregiving.Neurotoxicity research · 2025Article
- Article
- Effects of Early Life Scarcity-Adversity on Maturational Milestones in Male and Female Rats.Developmental psychobiology · 2024Article
- Depressive symptoms during the transition to adolescence: Left hippocampal volume as a marker of social context sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Prenatal alcohol exposure and early-life adversity: A translational perspective for dissecting compounding impacts.Alcohol, clinical & experimental research · 2023Article
- Neural Circuit Transitions Supporting Developmentally Specific Social Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Infant maltreatment increases vulnerability to physical and mental disorders, yet specific mechanisms embedded within this complex infant experience that induce this vulnerability remain elusive. To define critical features of maltreatment-induced vulnerability, rat pups were reared from postnatal day 8 (PN8) with a maltreating mother, which produced amygdala and hippocampal deficits and decreased social behavior at PN13. Next, we deconstructed the maltreatment experience to reveal sufficient and necessary conditions to induce this phenotype. Social behavior and amygdala deficits (volume, neurogenesis, c-Fos, local field potential) required combined chronic high corticosterone and maternal presence (not maternal behavior). Hippocampal deficits were induced by chronic high corticosterone regardless of social context. Causation was shown by blocking corticosterone during maltreatment and suppressing amygdala activity during social behavior testing. These results highlight (1) that early life maltreatment initiates multiple pathways to pathology, each with distinct causal mechanisms and outcomes, and (2) the importance of social presence on brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.