Evidence map›Paper›PMID 31636188›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the Congo.

Chad R Wells, Abhishek Pandey, Martial L Ndeffo Mbah, Bernard-A Gaüzère, Denis Malvy, Burton H Singer, Alison P Galvani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Misconceptions and Rumors about Ebola Virus Disease in Sub-Saharan Africa: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
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  18. Disease burden among Ukrainians forcibly displaced by the 2022 Russian invasion.Proceedings of the National Academy of Sciences of the United States of America · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Chad R WellsCenter for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06520.
Abhishek PandeyCenter for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06520.
Martial L Ndeffo MbahDepartment of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843.
Bernard-A GaüzèreCentre René Labusquière, Department of Tropical Medicine and Clinical International Health, University of Bordeaux, 33076 Bordeaux, France.
Denis MalvyCentre René Labusquière, Department of Tropical Medicine and Clinical International Health, University of Bordeaux, 33076 Bordeaux, France.
Burton H SingerEmerging Pathogens Institute, University of Florida, Gainesville, FL 32610 bhsinger@epi.ufl.edu.
Alison P GalvaniCenter for Infectious Disease Modeling and Analysis, Yale School of Public Health, New Haven, CT 06520.

Funding

Impacts of Individual and Social Behavior on Influenza Dynamics and ControlU01GM087719 · NIGMS · YALE UNIVERSITY · PI GALVANI, ALISON P, MEYERS, LAUREN ANCEL · 2009 to 2018
$6.3M
NIGMS NIH HHS U01 GM087719
6 · The paper itself

Abstract

The interplay between civil unrest and disease transmission is not well understood. Violence targeting healthcare workers and Ebola treatment centers in the Democratic Republic of the Congo (DRC) has been thwarting the case isolation, treatment, and vaccination efforts. The extent to which conflict impedes public health response and contributes to incidence has not previously been evaluated. We construct a timeline of conflict events throughout the course of the epidemic and provide an ethnographic appraisal of the local conditions that preceded and followed conflict events. Informed by temporal incidence and conflict data as well as the ethnographic evidence, we developed a model of Ebola transmission and control to assess the impact of conflict on the epidemic in the eastern DRC from April 30, 2018, to June 23, 2019. We found that both the rapidity of case isolation and the population-level effectiveness of vaccination varied notably as a result of preceding unrest and subsequent impact of conflict events. Furthermore, conflict events were found to reverse an otherwise declining phase of the epidemic trajectory. Our model framework can be extended to other infectious diseases in the same and other regions of the world experiencing conflict and violence.

Indexed as

Armed ConflictsDemocratic Republic of the CongoDisease OutbreaksHealth PersonnelHemorrhagic Fever, EbolaHumansIncidenceVaccinationepidemiologyhealthcare workershumanitarian crisisinsecurity

Identifiers

PMID31636188
PMCPMC6883813

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.