Evidence map›Paper›PMID 31636117›Full record

ArticleThe Journal of cell biology2019

Soluble tubulin is significantly enriched at mitotic centrosomes.

Johannes Baumgart, Marcel Kirchner, Stefanie Redemann, Alec Bond, Jeffrey Woodruff, Jean-Marc Verbavatz, Frank Jülicher, Thomas Müller-Reichert, Anthony A Hyman, Jan Brugués

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
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  11. Native molecular architectures of centrosomes inbioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Review
  14. Mechanisms underlying spindle assembly and robustness.Nature reviews. Molecular cell biology · 2023
    Review
  15. Article
  16. Article
  17. γ-Tubulin in microtubule nucleation and beyond.Frontiers in cell and developmental biology · 2022
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Johannes Baumgart *Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.ORCID 0000-0001-7384-5715
Marcel Kirchner *Experimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Stefanie RedemannExperimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0003-2334-7309
Alec BondDepartment of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX.
Jeffrey WoodruffMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0002-5590-9620
Jean-Marc VerbavatzMax Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Frank Jülicher *Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.
Thomas Müller-Reichert *Experimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.ORCID 0000-0003-0203-1436
Anthony A Hyman *Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.ORCID 0000-0003-3664-154X
Jan Brugués *Max Planck Institute for the Physics of Complex Systems, Dresden, Germany brugues@mpi-cbg.de.ORCID 0000-0002-6731-4130
Max Planck Institute of Molecular Cell Biology and Genetics · DEMax Planck Institute for the Physics of Complex Systems · DEUniversity Hospital Carl Gustav Carus · DEThe University of Texas Southwestern Medical Center · US

Funding

NEUROTRANSMITTER RECEPTORSK05DA000074 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SNYDER, SOLOMON H. · 1985 to 2009
$1.3M
NIDA NIH HHS K05 DA000074
6 · The paper itself

Abstract

During mitosis, the centrosome expands its capacity to nucleate microtubules. Understanding the mechanisms of centrosomal microtubule nucleation is, however, constrained by a lack of knowledge of the amount of soluble and polymeric tubulin at mitotic centrosomes. Here we combined light microscopy and serial-section electron tomography to measure the amount of dimeric and polymeric tubulin at mitotic centrosomes in early

Indexed as

MitosisAnimalsCaenorhabditis elegansCentrosomeCytoplasmDimerizationImage Processing, Computer-AssistedImaging, Three-DimensionalMetaphaseMicroscopy, ElectronMicrotubulesNocodazolePolymersRNA InterferenceSolubilityTubulinNocodazolePolymersTubulin

Identifiers

PMID31636117
PMCPMC6891098
OpenAlexW2981610884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.