Evidence map›Paper›PMID 31636064›Full record

ArticleAntimicrobial agents and chemotherapy2019

High-Level Carbapenem Resistance in OXA-232-Producing Raoultella ornithinolytica Triggered by Ertapenem Therapy.

Alina Iovleva, Roberta T Mettus, Christi L McElheny, Marissa P Griffith, Mustapha M Mustapha, A William Pasculle, Ryan K Shields, Vaughn S Cooper, Yohei Doi

Open access · greenAbstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Emergence ofFrontiers in microbiology · 2023
    Article
  4. Isolation ofAccess microbiology · 2022
    Article
  5. KPC-3-, GES-5-, and VIM-1-ProducingInternational journal of environmental research and public health · 2022
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Alina IovlevaDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Roberta T MettusDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Christi L McElhenyDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Marissa P GriffithDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mustapha M MustaphaDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4102-2965
A William PasculleClinical Microbiology Laboratory, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ryan K ShieldsDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Vaughn S CooperCenter for Innovative Antimicrobial Therapy, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7726-0765
Yohei DoiDivision of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA yod4@pitt.edu.
University of Pittsburgh · USFujita Health University · JP

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Colistin-resistant Acinetobacter baumanniiR01AI104895 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI, ERNST, ROBERT K · 2014 to 2024
$4.2M
Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasisK08AI114883 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2015 to 2019
$858k
Study Network of Acinetobacter as a Carbapenem-Resistant Pathogen (SNAP)R21AI135522 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DOI, YOHEI · 2018 to 2019
$460k
Characterization and suppression of resistance to new CRE agentsR03AI144636 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2019 to 2020
$157k
NIAID NIH HHS K08 AI114883NIAID NIH HHS R01 AI104895NIAID NIH HHS R03 AI144636NIAID NIH HHS R21 AI135522NIAID NIH HHS U01 AI124302NIGMS NIH HHS R01 GM110444
6 · The paper itself

Abstract

OXA-232 is an OXA-48-group class D β-lactamase that hydrolyzes expanded-spectrum cephalosporins and carbapenems at low levels. Clinical strains producing OXA-232 are sometimes susceptible to carbapenems, making it difficult to identify them in the clinical microbiology laboratory. We describe the development of carbapenem resistance in sequential clinical isolates of

Indexed as

beta-Lactam ResistanceBacterial Proteinsbeta-LactamasesCarbapenem-Resistant EnterobacteriaceaeCarbapenemsEnterobacteriaceaeEnterobacteriaceae InfectionsErtapenemGenes, BacterialHumansMaleMutationPorinsWhole Genome SequencingBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsErtapenemOmpC proteinOmpF proteinPorinscarbapenemasecarbapenem resistanceoxacillinase

Identifiers

PMID31636064
PMCPMC7187609
OpenAlexW2981075144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.