ArticleBiophysical journal2019
Mechanosensitive Junction Remodeling Promotes Robust Epithelial Morphogenesis.
Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Learning Epithelial Elasticity via Local Tension Remodeling.bioRxiv : the preprint server for biology · 2025Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Article
- Inferring active and passive mechanical drivers of epithelial convergent extension.bioRxiv : the preprint server for biology · 2025Article
- Stomatocyte-discocyte-echinocyte transformations of erythrocyte modulated by membrane-cytoskeleton mechanical properties.Biophysical journal · 2025Article
- Vertex model with internal dissipation enables sustained flows.Nature communications · 2025Article
- A minimal vertex model explains how the amnioserosa avoids fluidization duringProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mechanochemical bistability of intestinal organoids enables robust morphogenesis.Nature physics · 2025Article
- Graph topological transformations in space-filling cell aggregates.PLoS computational biology · 2024Article
- Excitable dynamics driven by mechanical feedback in biological tissues.Communications physics · 2024Article
- Article
- A mechanochemical model recapitulates distinct vertebrate gastrulation modes.Science advances · 2023Article
- The Effect of Substrate Stiffness on Elastic Force Transmission in the Epithelial Monolayers over Short Timescales.Cellular and molecular bioengineering · 2023Article
- Engineering tools for quantifying and manipulating forces in epithelia.Biophysics reviews · 2023Review
- APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells.iScience · 2023Article
- Article
- Two-point optical manipulation reveals mechanosensitive remodeling of cell-cell contacts in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell size and actin architecture determine force generation in optogenetically activated cells.Biophysical journal · 2023Article
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Authors and funding
5 authors.
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Abstract
Morphogenesis of epithelial tissues requires tight spatiotemporal coordination of cell shape changes. In vivo, many tissue-scale shape changes are driven by pulsatile contractions of intercellular junctions, which are rectified to produce irreversible deformations. The functional role of this pulsatory ratchet and its mechanistic basis remain unknown. Here we combine theory and biophysical experiments to show that mechanosensitive tension remodeling of epithelial cell junctions promotes robust epithelial shape changes via ratcheting. Using optogenetic control of actomyosin contractility, we find that epithelial junctions show elastic behavior under low contractile stress, returning to their original lengths after contraction, but undergo irreversible deformation under higher magnitudes of contractile stress. Existing vertex-based models for the epithelium are unable to capture these results, with cell junctions displaying purely elastic or fluid-like behaviors, depending on the choice of model parameters. To describe the experimental results, we propose a modified vertex model with two essential ingredients for junction mechanics: thresholded tension remodeling and continuous strain relaxation. First, junctions must overcome a critical strain threshold to trigger tension remodeling, resulting in irreversible junction length changes. Second, there is a continuous relaxation of junctional strain that removes mechanical memory from the system. This enables pulsatile contractions to further remodel cell shape via mechanical ratcheting. Taken together, the combination of mechanosensitive tension remodeling and junctional strain relaxation provides a robust mechanism for large-scale morphogenesis.
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