Evidence map›Paper›PMID 31635526›Full record

ReviewAnnual review of physiology2020

Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception.

Christi M Gendron, Tuhin S Chakraborty, Brian Y Chung, Zachary M Harvanek, Kristina J Holme, Jacob C Johnson, Yang Lyu, Allyson S Munneke, Scott D Pletcher

Open access · greenAbstract readReview
In one paragraph

Review in Annual review of physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Sociosexual Exposure Has Opposing Effects on Male and Female Actuarial Senescence in the Fruit Fly Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
    Article
  7. Article
  8. Light modulatesAging · 2023
    Article
  9. Accelerated neuronal agingFrontiers in aging neuroscience · 2022
    Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Christi M GendronDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Tuhin S ChakrabortyDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Brian Y ChungDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Zachary M HarvanekDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Kristina J HolmeDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Jacob C JohnsonDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Yang LyuDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
Allyson S MunnekeProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Scott D PletcherDepartment of Molecular and Integrative Physiology and the Geriatrics Center, University of Michigan, Ann Arbor, Michigan 48109, USA; email: spletch@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Research Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4M
Modulation of aging by Sensory PerceptionR01AG030593 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT · 2007 to 2025
$6.1M
Mechanisms of Dietary Restriction in DrosophilaR01AG023166 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT · 2004 to 2014
$2.9M
Modulation of aging through mechanisms of nutrient demand and rewardR37AG051649 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 2021 to 2026
$2.3M
The role of neural signaling pathways in costs of reproduction on agingR01AG063371 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT, PROMISLOW, DANIEL EDWARD · 2019 to 2023
$1.9M
Modulation of aging through mechanisms of nutrient demand and rewardR01AG051649 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PLETCHER, SCOTT · 2016 to 2020
$1.6M
NIA NIH HHS R01 AG023166NIA NIH HHS R01 AG030593NIA NIH HHS R01 AG051649NIA NIH HHS R01 AG063371NIA NIH HHS R37 AG051649NIA NIH HHS T32 AG000114NIDDK NIH HHS P30 DK020572NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Sensory neurons provide organisms with data about the world in which they live, for the purpose of successfully exploiting their environment. The consequences of sensory perception are not simply limited to decision-making behaviors; evidence suggests that sensory perception directly influences physiology and aging, a phenomenon that has been observed in animals across taxa. Therefore, understanding the neural mechanisms by which sensory input influences aging may uncover novel therapeutic targets for aging-related physiologies. In this review, we examine different perceptive experiences that have been most clearly linked to aging or age-related disease: food perception, social perception, time perception, and threat perception. For each, the sensory cues, receptors, and/or pathways that influence aging as well as the individual or groups of neurons involved, if known, are discussed. We conclude with general thoughts about the potential impact of this line of research on human health and aging.

Indexed as

AgingAnimalsCuesHumansPerceptionSensory Receptor CellsSignal Transductiondietmodel systemssensory perceptionsocial isolationthreat perceptiontime perception

Identifiers

PMID31635526
PMCPMC7012701
OpenAlexW2981715373

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.