Evidence map›Paper›PMID 31635396›Full record

ArticleNutrients2019

Vitamin D Improves Nitric Oxide-Dependent Vasodilation in Adipose Tissue Arterioles from Bariatric Surgery Patients.

Abeer M Mahmoud, Mary Szczurek, Chandra Hassan, Mario Masrur, Antonio Gangemi, Shane A Phillips

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  6. Review
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  12. ADAM17 cleaves the insulin receptor ectodomain on endothelial cells and causes vascular insulin resistance.American journal of physiology. Heart and circulatory physiology · 2022
    Article
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  14. Review on Headache Related to Dietary Supplements.Current pain and headache reports · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Abeer M MahmoudDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. amahmo4@uic.edu.
Mary SzczurekDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, IL 60612, USA. mszczurek@uic.edu.
Chandra HassanDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA. chandrar@uic.edu.
Mario MasrurDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA. mmasrur@uic.edu.
Antonio GangemiDepartment of Surgery, University of Illinois at Chicago, Chicago, IL 60612, USA. gangemi@uic.edu.
Shane A PhillipsDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA. shanep@uic.edu.
University of Illinois Chicago · US

Funding

Strengthening Stakeholder Engagement in Human Research Protections.UL1TR002003 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARNIK, NIRANJAN SUBHASH, MERMELSTEIN, ROBIN J. · 2016 to 2024
$33.7M
Shedding of Endothelial Glycocalyx in Morbidly Obese PatientsR00HL140049 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOHAMED, ABEER M · 2019 to 2021
$889k
DNA Methylation and Vascular Function in Obesity: Role of Exercise and Weight LossK99HL140049 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MOHAMED, ABEER M · 2018 to 2019
$213k
NCATS NIH HHS UL1 TR002003NHLBI NIH HHS K99 HL140049NHLBI NIH HHS R00 HL140049NIH HHS 4 R00 HL140049-03NIH HHS HL095701NIH HHS HL130513NIH HHS K99HL140049
6 · The paper itself

Abstract

There is a high prevalence of vitamin-D deficiency in obese individuals that could be attributed to vitamin-D sequestration in the adipose tissue. Associations between vitamin-D deficiency and unfavorable cardiometabolic outcomes were reported. However, the pathophysiological mechanisms behind these associations are yet to be established. In our previous studies, we demonstrated microvascular dysfunction in obese adults that was associated with reduced nitric oxide (NO) production. Herein, we examined the role of vitamin D in mitigating microvascular function in morbidly obese adults before and after weight loss surgery. We obtained subcutaneous (SAT) and visceral adipose tissue (VAT) biopsies from bariatric patients at the time of surgery (

Indexed as

AcetylcholineAdipose TissueAdultArteriolesBariatric SurgeryFemaleHumansHydrogen PeroxideMaleMiddle AgedNitric OxideTissue Culture TechniquesVasodilationVitamin DYoung AdultAcetylcholineHydrogen PeroxideNitric OxideVitamin Dbariatric surgerymicrovascularnitric oxideobesityvitamin Dweight loss

Identifiers

PMID31635396
PMCPMC6835261
OpenAlexW2980848375

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.