Evidence map›Paper›PMID 31635365›Full record

ReviewInsects2019

Natural Product Medicines for Honey Bees: Perspective and Protocols.

James P Tauber, William R Collins, Ryan S Schwarz, Yanping Chen, Kyle Grubbs, Qiang Huang, Dawn Lopez, Raymond Peterson, Jay D Evans

Open access · goldAbstract readReview
In one paragraph

Review in Insects, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 47 citations in OpenAlex.

  1. Metabolic Redox Modulation byMolecules (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Regulation ofFrontiers in insect science · 2026
    Article
  4. Recent Advancements in the Analyses of Natural Products.Combinatorial chemistry & high throughput screening · 2025
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Recent Advances in the Biocontrol of Nosemosis in Honey Bees (Journal of fungi (Basel, Switzerland) · 2022
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Japanese Honeybees (Insects · 2021
    Article
  17. Antiradical and Cytoprotective Properties ofFrontiers in pharmacology · 2021
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

James P TauberUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. james.tauber@usda.gov.
William R CollinsDepartment of Chemistry, Fort Lewis College, 1000 Rim Drive, Durango, CO 81301, USA. collins_w@fortlewis.edu.
Ryan S SchwarzDepartment of Biological Sciences, Fort Lewis College, 1000 Rim Drive, Durango, CO 81301, USA. rsschwarz@fortlewis.edu.
Yanping ChenUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. judy.chen@ars.usda.gov.
Kyle GrubbsUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. kyle.grubbs@ars.usda.gov.
Qiang HuangHoneybee Research Institute, Jiangxi Agricultural University, Zhimin Avenue 1101, Nanchang 330045, China. qiang-huang@live.com.
Dawn LopezUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. Dawn.Lopez@ars.usda.gov.
Raymond PetersonUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. raymond.peterson@granitepv.com.
Jay D EvansUSDA-ARS Bee Research Laboratory, BLDG. 306, RM. 315, BARC-EAST, Beltsville, MD 20705, USA. Jay.Evans@usda.gov.
Agricultural Research Service · USFort Lewis College · USJiangxi Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The western honey bee remains the most important pollinator for agricultural crops. Disease and stressors threaten honey bee populations and productivity during winter- and summertime, creating costs for beekeepers and negative impacts on agriculture. To combat diseases and improve overall bee health, researchers are constantly developing honey bee medicines using the tools of microbiology, molecular biology and chemistry. Below, we present a manifesto alongside standardized protocols that outline the development and a systematic approach to test natural products as 'bee medicines.' These will be accomplished in both artificial rearing conditions and in colonies situated in the field. Output will be scored by gene expression data of host immunity, bee survivorship, reduction in pathogen titers, and more subjective merits of the compound in question. Natural products, some of which are already encountered by bees in the form of plant resins and nectar compounds, provide promising low-cost candidates for safe prophylaxis or treatment of bee diseases.

Indexed as

bee diseasecolony losshoney beesnatural productscreeningtraditional medicinevirus

Identifiers

PMID31635365
PMCPMC6835950
OpenAlexW2981291653

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.