Evidence map›Paper›PMID 31635166›Full record

ArticleProteomes2019

Proteomic Analysis of 3T3-L1 Adipocytes Treated with Insulin and TNF-α.

Hayley Chan, Ketaki P Bhide, Aditya Vaidyam, Victoria Hedrick, Tiago Jose Paschoal Sobreira, Thomas G Sors, Ryan W Grant, Uma K Aryal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. ERO1-PDI Redox Signaling in Health and Disease.Antioxidants & redox signaling · 2021
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hayley ChanDepartment of Computer Science, Purdue University, West Lafayette, IN 47907, USA. hachan@iu.edu.
Ketaki P BhideCollege of Agriculture, Purdue University, West Lafayette, IN 47907, USA. bhide@purdue.edu.
Aditya VaidyamDepartment of Computer Science, Purdue University, West Lafayette, IN 47907, USA. avaidyam@purdue.edu.
Victoria HedrickPurdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA. vhedrick@purdue.edu.
Tiago Jose Paschoal SobreiraPurdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA. sobreira@purdue.edu.
Thomas G SorsPurdue Institute of Inflammation, Immunology and Infectious Disease, Purdue University, West Lafayette, IN 47907, USA. tsors@purdue.edu.
Ryan W GrantDepartment of Nutrition Science, Purdue University, West Lafayette, IN 47907, USA. r.w.grant@gmail.com.ORCID 0000-0002-8940-4196
Uma K AryalPurdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA. uaryal@purdue.edu.ORCID 0000-0003-4543-1536
Purdue University West Lafayette · US

Funding

Indiana Clinical and Translational Sciences Institute #UL1 TR001108
6 · The paper itself

Abstract

Insulin resistance is an indication of early stage Type 2 diabetes (T2D). Insulin resistant adipose tissues contain higher levels of insulin than the physiological level, as well as higher amounts of intracellular tumor necrosis factor-α (TNF-α) and other cytokines. However, the mechanism of insulin resistance remains poorly understood. To better understand the roles played by insulin and TNF-α in insulin resistance, we performed proteomic analysis of differentiated 3T3-L1 adipocytes treated with insulin (Ins), TNF-α (TNF), and both (Ins + TNF). Out of the 693 proteins identified, the abundances of 78 proteins were significantly different (

Indexed as

3T3-L cellsinsulinmass spectrometryquantitative proteomicstumor necrosis factor-αtype II diabetes

Identifiers

PMID31635166
PMCPMC6958341
OpenAlexW2980869152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.