Evidence map›Paper›PMID 31635165›Full record

SynthesisNutrients2019

Effect of the Combination of Creatine Monohydrate Plus HMB Supplementation on Sports Performance, Body Composition, Markers of Muscle Damage and Hormone Status: A Systematic Review.

Julen Fernández-Landa, Julio Calleja-González, Patxi León-Guereño, Alberto Caballero-García, Alfredo Córdova, Juan Mielgo-Ayuso

Registry-linked trialOpen access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07275996 (Effects of Creatine Monohydrate and β-Hydroxy-β-Methylbutyrate Supplementation Combined With Multicomponent Exercise on Physical Performance, Cognition and Quality of Life in Institutionalized Older Adults), which is not on this map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07275996 naactive not recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Creatine Monohydrate and β-Hydroxy-β-Methylbutyrate Supplementation Combined With Multicomponent Exercise on Physical Performance, Cognition and Quality of Life in Institutionalized Older Adults: A Randomized Double-Blind Parallel-Group Trial

TypeinterventionalSponsorUniversidad de BurgosRan2026 to 2027Enrolled50ConditionsFrailty, Sarcopenia, Aging, Malnutrition ElderlyArmsPlacebo (Cellulose), Creatine Monohydrate, Multicomponent Exercise Program, β-Hydroxy-β-Methylbutyrate (HMB)
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  3. Frontiers in nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Julen Fernández-LandaLaboratory of Human Performance, Department of Physical Education and Sport, Faculty of Education, Sport Section, University of the Basque Country, 01007 Vitoria, Spain. julenfdl@hotmail.com.ORCID 0000-0003-2900-1712
Julio Calleja-GonzálezLaboratory of Human Performance, Department of Physical Education and Sport, Faculty of Education, Sport Section, University of the Basque Country, 01007 Vitoria, Spain. julio.calleja.gonzalez@gmail.com.
Patxi León-GuereñoFaculty of Psychology and Education, University of Deusto, Campus of Donostia-San Sebastián, 20012 San Sebastián, Spain. patxi.leon@deusto.es.ORCID 0000-0003-2772-9128
Alberto Caballero-GarcíaDepartment of Anatomy and Radiology, Faculty of Health Sciences, University of Valladolid. Campus de Soria, 42003 Soria, Spain. albcab@ah.uva.es.
Alfredo CórdovaDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, University of Valladolid, 42003 Soria, Spain. a.cordova@bio.uva.es.
Juan Mielgo-AyusoDepartment of Biochemistry, Molecular Biology and Physiology, Faculty of Health Sciences, University of Valladolid, 42003 Soria, Spain. juanfrancisco.mielgo@uva.es.ORCID 0000-0002-6554-4602
Universidad de Valladolid · ESUniversity of the Basque Country · ESUniversidad de Deusto · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although there are many studies showing the isolated effect of creatine monohydrate (CrM) and β-hydroxy β-methylbutyrate (HMB), it is not clear what effect they have when they are combined. The main purpose of this systematic review was to determine the efficacy of mixing CrM plus HMB in comparison with their isolated effects on sports performance, body composition, exercise induced markers of muscle damage, and anabolic-catabolic hormones. This systematic review was carried out in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement guidelines and the PICOS model, for the definition of the inclusion criteria. Studies were found by searching PubMed/MEDLINE, Web of Science (WOS), and Scopus electronic databases from inception to July 3rd 2019. Methodological quality and risk of bias were assessed by two authors independently, and disagreements were resolved by third-party evaluation, in accordance with the Cochrane Collaboration Guidelines samples. The literature was examined regarding the effects of the combination of CrM plus HMB on sport performance using several outcome variables (athletic performance, body composition, markers of muscle damage, and hormone status). This systematic review included six articles that investigated the effects of CrM plus HMB on sport performance (two on strength performance, showing improvements in one of them; three on anaerobic performance, presenting enhancements in two of them; and one on aerobic performance, not presenting improvements), body composition (three on body mass, showing improvements in one of them; two on fat free mass, presenting increases in one of them; and two on fat mass, showing decreases in one of them) and markers of muscle damage and hormone status (four on markers of muscle damage and one on anabolic-catabolic hormones, not showing benefits in any of them). In summary, the combination of 3-10 g/day of CrM plus 3 g/day of HMB for 1-6 weeks could produce potential positive effects on sport performance (strength and anaerobic performance) and for 4 weeks on body composition (increasing fat free mass and decreasing fat mass). However, this combination seems to not show positive effects relating to markers of exercise-induced muscle damage and anabolic-catabolic hormones.

Indexed as

Athletic PerformanceBody CompositionCreatineHumansMuscular DiseasesSportsValeratesbeta-hydroxyisovaleric acidCreatineValeratesaerobicanaerobicbody compositionmuscle recoverysport nutrition

Identifiers

PMID31635165
PMCPMC6835217
OpenAlexW2981072166

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.