Evidence map›Paper›PMID 31635081›Full record

ArticleInternational journal of molecular sciences2019

Determination of the Pathological Features of NPC1 Variants in a Cellular Complementation Test.

Xiao Feng, Claudia Cozma, Supansa Pantoom, Christina Hund, Katharina Iwanov, Janine Petters, Christin Völkner, Claudia Bauer, Florian Vogel, Peter Bauer and 8 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Xiao FengTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. xiao.feng@uni-rostock.de.
Claudia CozmaCentogene AG, 18055 Rostock, Germany. claudia.cozma@centogene.com.
Supansa PantoomTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. supansa.pantoom@med.uni-rostock.de.ORCID 0000-0001-9630-1999
Christina HundTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. christina.hund@med.uni-rostock.de.
Katharina IwanovTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. katharina.iwanov@med.uni-rostock.de.
Janine PettersTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. janine.petters@med.uni-rostock.de.
Christin VölknerTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. christin.voelkner@med.uni-rostock.de.
Claudia BauerCentogene AG, 18055 Rostock, Germany. claudia.bauer@centogene.com.
Florian VogelCentogene AG, 18055 Rostock, Germany. florian.vogel@centogene.com.
Peter BauerCentogene AG, 18055 Rostock, Germany. peter.bauer@centogene.com.
Frank U WeissDepartment of Medicine A, University Medicine Greifswald, 17489 Greifswald, Germany. ulrich.weiss@uni-greifswald.de.
Markus M LerchDepartment of Medicine A, University Medicine Greifswald, 17489 Greifswald, Germany. Markus.Lerch@med.uni-greifswald.de.
Anne-Marie KnospeTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. anne.knospe@neuroproof.com.
Andreas HermannTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. andreas.hermann@med.uni-rostock.de.
Moritz J FrechTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. moritz.frech@med.uni-rostock.de.ORCID 0000-0003-2421-8779
Jiankai LuoTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. jiankai.luo@med.uni-rostock.de.
Arndt RolfsCentogene AG, 18055 Rostock, Germany. arndt.rolfs@centogene.com.
Jan LukasTranslational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, University of Rostock, 18147 Rostock, Germany. jan.lukas@med.uni-rostock.de.
University of Rostock · DECentogene (Germany) · DEUniversitätsmedizin Greifswald · DEGerman Center for Neurodegenerative Diseases · DE

Funding

European Regional Development Fund TBI-V-1-082-VBW-028European Regional Development Fund TBI-V-1-083-VBW-028European Union Social Fund ESF/14-BM-A55-0045/16European Union Social Fund ESF/14-BM-A55-0046/16
6 · The paper itself

Abstract

Niemann-Pick Type C (NP-C) is a rare disorder of lipid metabolism caused by mutations within the

Indexed as

Genetic Complementation TestGenetic VariationAllelesAmino Acid SequenceAnimalsCells, CulturedCHO CellsCholesterolChromosome MappingCricetulusGene FrequencyGenetic Association StudiesGenotypeHumansIntracellular Signaling Peptides and ProteinsModels, MolecularCholesterolIntracellular Signaling Peptides and ProteinsNiemann-Pick C1 ProteinNPC1 protein, humanlipid metabolismliver diseasepharmacological chaperonevariant of unknown significance

Identifiers

PMID31635081
PMCPMC6834306
OpenAlexW2980840158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.