ArticleAnnals of internal medicine2019
Life-Gained-Based Versus Risk-Based Selection of Smokers for Lung Cancer Screening.
Article in Annals of internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07073898 (Population Health Management Approaches to Increase Lung Cancer Screening in Community Health Centers - UG3 Pilot Clinical Trial), which is not on this map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Population Health Management Approaches to Increase Lung Cancer Screening in Community Health Centers - UG3 Pilot Clinical Trial
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- The influence of postscreening follow-up time and participant characteristics on estimates of overdiagnosis from lung cancer screening trials.International journal of cancer · 2022Pooled it
- Guideline
- Guideline
- Enhancement of Patient-Centered Lung Cancer Screening: The MyLungHealth Randomized Clinical Trial.JAMA oncology · 2026Trial
- A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials.Nature communications · 2025Trial
- Why Women Appear to Have Better Outcomes When Undergoing Screening for Lung Cancer.Annals of the American Thoracic Society · 2025Trial
- Trial
- Feasibility and acceptability of an everyday patient-centered discussion model for primary care: An exploratory, single-center study in the VA primary care setting.PEC innovation · 2026Article
- Moving From Individualized Risk-Based Prevention to Benefit-Based Prevention: Estimating Individualized Life-Years Gained From Prevention Services as a Basis for Eligibility.Statistics in medicine · 2026Article
- Improving lung cancer screening diagnostic efficiency.Current opinion in pulmonary medicine · 2026Review
- Personalizing lung cancer screening recommendations for heterogeneous populations: a microsimulation study.Journal of the National Cancer Institute · 2026Article
- Comparison of Underlying Risk of Developing and Dying From Lung Cancer in Screened Populations.Chest · 2026Article
- Defining eligibility for lung cancer screening based on individual risk.The Lancet. Oncology · 2025Article
- An Everyday Patient-Centered Discussion Model for Primary Care: Protocol for a Feasibility and Acceptability Study of the Zeroing in on Individualized, Patient-Centered Decisions (ZIP) Approach.JMIR research protocols · 2025Article
- Updates in Lung Cancer Screening: A Decade of Evidence.Seminars in respiratory and critical care medicine · 2025Review
- Review
- Lung Cancer Screening in Cancer Survivors vs Those Without a History of Cancer.JAMA network open · 2025Article
- The quality of patient decision aids for lung cancer screening: Results from an environmental scan.Cancer · 2025Review
- Do Differences in Comorbidity Explain Sex-based Differences in Lung Cancer Screening Outcomes?Annals of the American Thoracic Society · 2025Article
- Eligibility criteria for lung cancer screening in France: a modelling study.The Lancet regional health. Europe · 2025Article
13 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Although risk-based selection of ever-smokers for screening could prevent more lung cancer deaths than screening according to the U.S. Preventive Services Task Force (USPSTF) guidelines, it preferentially selects older ever-smokers with shorter life expectancies due to comorbidities. Objective: To compare selection of ever-smokers for screening based on gains in life expectancy versus lung cancer risk. Design: Cohort analyses and model-based projections. Setting: U.S. population of ever-smokers aged 40 to 84 years. Participants: 130 964 National Health Interview Survey participants, representing about 60 million U.S. ever-smokers during 1997 to 2015. Intervention: Annual computed tomography (CT) screening for 3 years versus no screening. Measurements: Estimated number of lung cancer deaths averted and life-years gained after development of a mortality model. Results: Using the calibrated and validated mortality model in U.S. ever-smokers aged 40 to 84 years and selecting 8.3 million ever-smokers to match the number selected by the USPSTF criteria in 2013 to 2015, the analysis estimated that life-gained-based selection would increase the total life expectancy from CT screening (633 400 vs. 607 800 years) but prevent fewer lung cancer deaths (52 600 vs. 55 000) compared with risk-based selection. The 1.56 million persons selected by the life-gained-based strategy but not the risk-based strategy were younger (mean age, 59 vs. 75 years) and had fewer comorbidities (mean, 0.75 vs. 3.7). Limitation: Estimates are model-based and assume implementation of lung cancer screening with short-term effectiveness similar to that from trials. Conclusion: Life-gained-based selection could maximize the benefits of lung cancer screening in the U.S. population by including ever-smokers who have both high lung cancer risk and long life expectancy. Primary Funding Source: Intramural Research Program of the National Cancer Institute, National Institutes of Health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.