Evidence map›Paper›PMID 31634824›Full record

ArticleIEEE transactions on bio-medical engineering2020

In Vivo Wireless Sensors for Gut Microbiome Redox Monitoring.

Spyridon Baltsavias, Will Van Treuren, Marcus J Weber, Jayant Charthad, Sam Baker, Justin L Sonnenburg, Amin Arbabian

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on bio-medical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
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  12. Review
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  14. Ultrasonic Implant Localization for Wireless Power Transfer: Active Uplink and Harmonic Backscatter.IEEE International Ultrasonics Symposium : [proceedings]. IEEE International Ultrasonics Symposium · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Spyridon Baltsavias
Will Van Treuren
Marcus J Weber
Jayant Charthad
Sam Baker
Justin L Sonnenburg
Amin Arbabian
Stanford University · USSamford University · US

Funding

A Wireless, Implantable Microdevice for Closed-Loop Drug Delivery to Prevent the Morbidity of Diabetes Therapy-Induced HypoglycemiaR01EB025867 · NIBIB · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2018 to 2021
$2.2M
In vivo Wireless Sensors for Gut Redox Monitoring to Understand Host and Microbe PhysiologyR21AI163489 · NIAID · STANFORD UNIVERSITY · PI ARBABIAN, AMIN · 2021 to 2022
$434k
NIAID NIH HHS R21 AI163489NIBIB NIH HHS R01 EB025867
6 · The paper itself

Abstract

A perturbed gut microbiome has recently been linked with multiple disease processes, yet researchers currently lack tools that can provide in vivo, quantitative, and real-time insight into these processes and associated host-microbe interactions. We propose an in vivo wireless implant for monitoring gastrointestinal tract redox states using oxidation-reduction potentials (ORP). The implant is powered and conveniently interrogated via ultrasonic waves. We engineer the sensor electronics, electrodes, and encapsulation materials for robustness in vivo, and integrate them into an implant that endures autoclave sterilization and measures ORP for 12 days implanted in the cecum of a live rat. The presented implant platform paves the way for long-term experimental testing of biological hypotheses, offering new opportunities for understanding gut redox pathophysiology mechanisms, and facilitating translation to disease diagnosis and treatment applications.

Indexed as

Gastrointestinal MicrobiomeAnimalsElectrodesElectronicsOxidation-ReductionProstheses and ImplantsRats

Identifiers

PMID31634824
PMCPMC7170758
OpenAlexW2916443881

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.