Evidence map›Paper›PMID 31634674›Full record

ReviewCurrent opinion in neurobiology2019

Transgenerational epigenetic inheritance: from phenomena to molecular mechanisms.

Noa Liberman, Simon Yuan Wang, Eric Lieberman Greer

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed.

  1. Article
  2. Identifying RNA acInterdisciplinary sciences, computational life sciences · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Emerging opportunities for DNA methylation biomarkers in cattle improvement.The Journal of reproduction and development · 2026
    Review
  7. Review
  8. Article
  9. Epigenetic Echoes: Bridging Nature, Nurture, and Healing Across Generations.International journal of molecular sciences · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Review
  18. A natural bacterial pathogen ofbioRxiv : the preprint server for biology · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noa LibermanDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA.
Simon Yuan WangDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA.
Eric Lieberman GreerDivision of Newborn Medicine, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston MA 02115, USA. Electronic address: eric.greer@childrens.harvard.edu.

Funding

Characterization of DNA N6-methyl adenine and its role in epigenetic memoryDP2AG055947 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2016 to 2021
$3.2M
Identifying the molecular mechanisms of transgenerational epigenetic inheritanceR00AG043550 · NIA · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2015 to 2017
$737k
Base-resolution sequencing of 6mA in eukaryotic DNAR21HG010066 · NHGRI · BOSTON CHILDREN'S HOSPITAL · PI GREER, ERIC LIEBERMAN · 2018 to 2019
$487k
NHGRI NIH HHS R21 HG010066NIA NIH HHS DP2 AG055947NIA NIH HHS R00 AG043550
6 · The paper itself

Abstract

Inherited information not encoded in the DNA sequence can regulate a variety of complex phenotypes. However, how this epigenetic information escapes the typical epigenetic erasure that occurs upon fertilization and how it regulates behavior is still unclear. Here we review recent examples of brain related transgenerational epigenetic inheritance and delineate potential molecular mechanisms that could regulate how non-genetic information could be transmitted.

Indexed as

Epigenesis, GeneticEpigenomicsDNA MethylationPhenotype

Identifiers

PMID31634674
PMCPMC6889819

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.