ArticleBiomaterials2020
Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug.
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Article in Biomaterials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Nanozyme hydrogels remodel pathological microenvironment for temporomandibular joint osteoarthritis therapy via inhibiting MAPK signal pathway.Bioactive materials · 2026Article
- Nell-1 regulates fibrocartilage stem cells and alleviates temporomandibular joint osteoarthritis progression by inhibiting hedgehog pathway.Journal of orthopaedic surgery and research · 2026Article
- NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026Review
- Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases.Bone research · 2025Article
- Nell-1 inhibits lipopolysaccharide-activated macrophages into M1 phenotype through the modulation of NF-κB pathway.Journal of molecular histology · 2025Article
- Trophic and temporal dynamics of macrophage biology in human inner ear organogenesis.Frontiers in immunology · 2025Article
- Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025Review
- Circulating tumor cells: from new biological insights to clinical practice.Signal transduction and targeted therapy · 2024Review
- Neural EGFL-like 1, a craniosynostosis-related osteochondrogenic molecule, strikingly associates with neurodevelopmental pathologies.Cell & bioscience · 2023Article
- A single nuclei atlas of aging human abdominal subcutaneous white adipose tissue.Research square · 2023Article
- The Current Role of Disease-modifying Osteoarthritis Drugs.The archives of bone and joint surgery · 2023Review
- The molecular link between obstructive sleep apnea and osteoarthritis: based on bioinformatics analysis and experimental validation.American journal of translational research · 2023Article
- Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2022Article
- NELL-1 in Genome-Wide Association Studies across Human Diseases.The American journal of pathology · 2022Review
- The current state of the osteoarthritis drug development pipeline: a comprehensive narrative review of the present challenges and future opportunities.Therapeutic advances in musculoskeletal disease · 2022Review
- Evaluation of Biomarkers and Immune Microenvironment of Osteoarthritis: Evidence From Omics Data and Machine Learning.Frontiers in genetics · 2022Article
- Mechanical Induction of Osteoarthritis Traits in a Cartilage-on-a-Chip Model.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Excavating bioactivities of nanozyme to remodel microenvironment for protecting chondrocytes and delaying osteoarthritis.Bioactive materials · 2021Article
- Nell-1 attenuates lipopolysaccharide-induced inflammation in human dental pulp cells.Journal of molecular histology · 2021Article
- Males and Females Have Distinct Molecular Events in the Articular Cartilage during Knee Osteoarthritis.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Chenshuang LiDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: chenshuanglee@gmail.com.
Zhong ZhengDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: zzheng@dentistry.ucla.edu.
Pin HaDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: hapin1987@ucla.edu.
Wenlu JiangDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: wlulujiang@outlook.com.
Emily A BerthiaumeDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: EBerthiaume@mednet.ucla.edu.
Seungjun LeeDepartment of Chemistry and Biochemistry, School of Letters and Science, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: seung7902@ucla.edu.
Zane MillsDepartment of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: zane.mills4823@gmail.com.
Hsinchuan PanDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: leinadp@gmail.com.
Eric C ChenDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: ericchenucla@g.ucla.edu.
Jie JiangDivision of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: jie.jiang@som.umaryland.edu.
Cymbeline T CuliatNellOne Therapeutics, Inc., Oak Ridge, TN, 37830, USA. Electronic address: cymbeline@nell-one.com.
Xinli ZhangDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: xinli@ucla.edu.
Kang TingDivision of Growth and Development, Section of Orthodontics, School of Dentistry, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: kting@dentistry.ucla.edu.
Chia SooDivision of Plastic and Reconstructive Surgery and Department of Orthopaedic Surgery and the Orthopaedic Hospital Research Center, University of California, Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: bsoo@ucla.edu.
University of California, Los Angeles · USOrthopaedic Hospital · US
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MNELL-1's functional role in cartilage regenerationR01AR068835 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, SOO, CHIA · 2015 to 2019
$2.2MNELL-1 Systemic Therapy for OsteoporosisR01AR066782 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EASLEY, JEREMIAH, TING, KANG · 2014 to 2018
$2.0MMultiphoton Microscope for Deep Tissue ImagingS10OD025017 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BENTOLILA, LAURENT A. · 2018 to 2018
$599kNCATS NIH HHS UL1 TR001881NIAMS NIH HHS R01 AR066782NIAMS NIH HHS R01 AR068835NIH HHS S10 OD025017
Abstract
Arthritis, an inflammatory condition that causes pain and cartilage destruction in joints, affects over 54.4 million people in the US alone. Here, for the first time, we demonstrated the emerging role of neural EGFL like 1 (NELL-1) in arthritis pathogenesis by showing that Nell-1-haploinsufficient (Nell-1
Indexed as
Cartilage, ArticularOsteoarthritisPharmaceutical PreparationsAnimalsAnti-Inflammatory AgentsCalcium-Binding ProteinsChondrocytesChondrogenesisInterleukin-1betaMiceAnti-Inflammatory AgentsCalcium-Binding ProteinsInterleukin-1betaNell1 protein, mousePharmaceutical PreparationsCartilage damageDisease-modifying osteoarthritis drug (DMOAD)InflammationNeural EGFL like 1 (NELL-1)OsteoarthritisRunt-related transcription factor 1 (RUNX1)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.