Trial reportSchizophrenia bulletin2020
Single Session Transcranial Magnetic Stimulation Ameliorates Hand Gesture Deficits in Schizophrenia.
Trial report in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Safety of rTMS for Schizophrenia: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2025Pooled it
- Theta Burst Stimulation Protocols for Schizophrenia: A Systematic Review and Network Meta-Analysis.JAMA network open · 2024Pooled it
- Emotion Recognition Deficits in Psychiatric Disorders as a Target of Non-invasive Neuromodulation: A Systematic Review.Clinical EEG and neuroscience · 2022Pooled it
- Gesture deficits in psychosis and the combination of group psychotherapy and transcranial magnetic stimulation: A randomized clinical trial.Molecular psychiatry · 2025Trial
- Aberrant gesture use in autism spectrum disorders is unrelated to motor abnormalities.European archives of psychiatry and clinical neuroscience · 2026Article
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- Functional organization of the primary motor cortex in psychosis and the potential role of intereffector regions in psychomotor slowing.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Defining and Engaging a Novel rTMS Target for Nicotine Craving in Psychotic Disorders.medRxiv : the preprint server for health sciences · 2025Article
- Speech-Gesture Matching and Schizotypal Traits: A Network Approach.Schizophrenia bulletin · 2025Article
- Neuromodulation in the treatment of social cognition dysfunction in Schizophrenia: a systematic review.Schizophrenia (Heidelberg, Germany) · 2025Review
- Brain network of athletes in motor imagery and action anticipation: an ALE meta-analysis and MACM analysis.Frontiers in sports and active living · 2025Review
- Intermittent theta burst stimulation enhances prefrontal activation and connectivity: evidence from fNIRS.Frontiers in human neuroscience · 2025Article
- Apraxia: From Neuroanatomical Pathways to Clinical Manifestations.Current neurology and neuroscience reports · 2024Review
- Adjunctive Intermittent Theta-Burst Stimulation for Schizophrenia: A Systematic Review and Meta-analysis of Randomized Double-Blind Controlled Studies.Alpha psychiatry · 2024Review
- Three principles for the utility of simple tasks that assess elemental processes in parsing heterogeneity.Journal of psychopathology and clinical science · 2024Article
- Isolation of Distinct Networks Driving Action and Cognition in Psychomotor Processes.Biological psychiatry · 2024Article
- Is depression a global brain disorder with topographic dynamic reorganization?Translational psychiatry · 2024Review
- Review
- The Behavioral Mapping of Psychomotor Slowing in Psychosis Demonstrates Heterogeneity Among Patients Suggesting Distinct Pathobiology.Schizophrenia bulletin · 2023Article
- A Systematic Review of Intermittent Theta Burst Stimulation for Neurocognitive Dysfunction in Older Adults with Schizophrenia.Journal of personalized medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social interaction is impaired in schizophrenia, including the use of hand gestures, which is linked to poor social perception and outcome. Brain imaging suggests reduced neural activity in a left-lateralized frontoparietal network during gesture preparation; therefore, gesturing might be improved through facilitation of left hemispheric brain areas or via disruption of interhemispheric inhibition from the right homolog. This study tested whether repetitive transcranial magnetic stimulation (rTMS) protocols would improve gesture performance in schizophrenia. This randomized, placebo-controlled, double-blind, crossover trial applied 3 different protocols of rTMS separated by 48 h. Twenty right-handed schizophrenia patients and 20 matched healthy controls received facilitatory intermittent theta burst stimulation (iTBS) over the left inferior frontal gyrus (IFG), inhibitory continuous theta burst stimulation (cTBS) over right inferior parietal lobe (IPL), and placebo over left IPL in randomized order. Primary outcome was change in the test of upper limb apraxia (TULIA), rated from video recordings of hand gesture performance. Secondary outcome was change in manual dexterity using the coin rotation task. Participants improved on both tasks following rTMS compared with baseline. Only patients improved gesture performance following right IPL cTBS compared with placebo (P = .013). The results of the coin rotation parallel those of the TULIA, with improvements following right IPL cTBS in patients (P = .001). Single sessions of cTBS on the right IPL substantially improved both gesture performance accuracy and manual dexterity. The findings point toward an inhibition of interhemispheric rivalry as a potential mechanism of action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.