ArticlePloS one2019
BMAL1 associates with chromosome ends to control rhythms in TERRA and telomeric heterochromatin.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Role of circadian CLOCK signaling in cellular senescence.Biogerontology · 2025Review
- The Anti-Elixir Triad: Non-Synced Circadian Rhythm, Gut Dysbiosis, and Telomeric Damage.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Review
- Progress in understanding how clock genes regulate aging and associated metabolic processes.Frontiers in physiology · 2025Review
- The role of vitamin D in sleep regulation: mechanisms, clinical advances, and future directions.Frontiers in nutrition · 2025Review
- TERRA and Telomere Maintenance in the YeastGenes · 2023Review
- TERRA beyond cancer: the biology of telomeric repeat-containing RNAs in somatic and germ cells.Frontiers in aging · 2023Review
- Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease.BMC pulmonary medicine · 2022Article
- Review
- BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates.Nucleic acids research · 2022Article
- Obstructive Sleep Apnea as an Acceleration Trigger of Cellular Senescence Processes through Telomere Shortening.International journal of molecular sciences · 2021Review
- Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration.Cell research · 2021Article
- Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The circadian clock and aging are intertwined. Disruption to the normal diurnal rhythm accelerates aging and corresponds with telomere shortening. Telomere attrition also correlates with increase cellular senescence and incidence of chronic disease. In this report, we examined diurnal association of White Collar 2 (WC-2) in Neurospora and BMAL1 in zebrafish and mice and found that these circadian transcription factors associate with telomere DNA in a rhythmic fashion. We also identified a circadian rhythm in Telomeric Repeat-containing RNA (TERRA), a lncRNA transcribed from the telomere. The diurnal rhythm in TERRA was lost in the liver of Bmal1-/- mice indicating it is a circadian regulated transcript. There was also a BMAL1-dependent rhythm in H3K9me3 at the telomere in zebrafish brain and mouse liver, and this rhythm was lost with increasing age. Taken together, these results provide evidence that BMAL1 plays a direct role in telomere homeostasis by regulating rhythms in TERRA and heterochromatin. Loss of these rhythms may contribute to telomere erosion during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.