ArticleCritical care medicine2019
Incidence and Outcomes of Acute Laryngeal Injury After Prolonged Mechanical Ventilation.
Article in Critical care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06939361 (The Tube Size Randomized Trial During Emergency Tracheal Intubation), which is not on this map. Cited by 67 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Tube Size Randomized Trial During Emergency Tracheal Intubation
Who cites it
67 citing papers in PubMed, 2 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Persistent Features of Laryngeal Injury Following Endotracheal Intubation: A Systematic Review.Dysphagia · 2023Pooled it
- Diagnostic efficacy of sonographic measurement of laryngeal air column width difference for predicting the risk of post-extubation stridor: A meta-analysis of observational studies.Frontiers in medicine · 2023Pooled it
- Ventilator settings for fiberoptic bronchoscopy during mechanical ventilation: a randomized adjudicator-blinded controlled trial VentSetFib.Critical care (London, England) · 2026Trial
- Feasibility of Endoscopic Evaluations of Laryngeal Function After Extubation for Research in Critically Ill Adults.American journal of speech-language pathology · 2025Trial
- Evaluating the Efficacy of Chitosan-l-DOPA MAP Gel for Acute Laryngeal Injury.Laryngoscope investigative otolaryngology · 2026Article
- Airway Anatomy as a Predictor of Tracheostomy in Critically Ill Patients: A Multicampus Analysis of Airway Grade, Admission Diagnosis, and Clinical Trajectory.Laryngoscope investigative otolaryngology · 2026Article
- Observational
- Short-Term Voice Changes After Endotracheal Intubation: Comparative Study of Head/Neck and Abdominal Surgery.Journal of clinical medicine · 2026Article
- Tilorone suppresses TGF-β-driven fibroblast activation and restores BMP-Smad1/5/8 signaling: implications for laryngotracheal fibrosis.Journal of translational medicine · 2026Article
- Factors Associated with Severity of Post-Intubation Cicatricial Laryngeal Stenosis in Children: A Retrospective Study.Journal of clinical medicine · 2026Article
- Intubated COVID-19 Patients More Likely to Develop Subglottic Stenosis.Laryngoscope investigative otolaryngology · 2026Article
- A Novel Murine Model of Acute Laryngeal Injury After Intubation.The Laryngoscope · 2026Article
- Development of a Clinically Relevant Rabbit Model of Acute Laryngeal Injury.Laryngoscope investigative otolaryngology · 2025Article
- Post-COVID-19 Dysphonia: Risk, Voice Handicap, and Laryngological Findings in COVID-19 Critical Illness Survivors.International archives of otorhinolaryngology · 2025Article
- Tracheal Stenosis and its Management - A Single Institution 10 Years Experience.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Evidence-based Emergency Tracheal Intubation.American journal of respiratory and critical care medicine · 2025Review
- Incidence and Risk Factors of Dysphagia After Cardiac Surgery: A Scoping Review.Journal of clinical medicine · 2025Review
- Size Matters: Endotracheal Tube Sizes and Glottic Stenosis Familiarity Among Intubating Physicians.Laryngoscope investigative otolaryngology · 2025Article
- Evaluation and Treatment of Acute Laryngeal Injury at Time of Tracheostomy for Prolonged Intubation.The Annals of otology, rhinology, and laryngology · 2025Article
- The forgotten airway: central airway pathology in the ICU.Frontiers in medicine · 2025Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesUpper airway injury is a recognized complication of prolonged endotracheal intubation, yet little attention has been paid to the consequences of laryngeal injury and functional impact. The purpose of our study was to prospectively define the incidence of acute laryngeal injury and investigate the impact of injury on breathing and voice outcomes.
designProspective cohort study.
settingTertiary referral critical care center. PATIENTS: Consecutive adult patients intubated greater than 12 hours in the medical ICU from August 2017 to May 2018 who underwent laryngoscopy within 36 hours of extubation.
interventionsLaryngoscopy following endotracheal intubation. MEASUREMENTS AND MAIN
resultsOne hundred consecutive patients (62% male; median age, 58.5 yr) underwent endoscopic examination after extubation. Acute laryngeal injury (i.e., mucosal ulceration or granulation tissue in the larynx) was present in 57 patients (57%). Patients with laryngeal injury had significantly worse patient-reported breathing (Clinical Chronic Obstructive Pulmonary Disease Questionnaire: median, 1.05; interquartile range, 0.48-2.10) and vocal symptoms (Voice Handicap Index-10: median, 2; interquartile range, 0-6) compared with patients without injury (Clinical Chronic Obstructive Pulmonary Disease Questionnaire: median, 0.20; interquartile range, 0-0.80; p < 0.001; and Voice Handicap Index-10: median, 0; interquartile range, 0-1; p = 0.005). Multivariable logistic regression independently associated diabetes, body habitus, and endotracheal tube size greater than 7.0 with the development of laryngeal injury.
conclusionsAcute laryngeal injury occurs in more than half of patients who receive mechanical ventilation and is associated with significantly worse breathing and voicing 10 weeks after extubation. An endotracheal tube greater than size 7.0, diabetes, and larger body habitus may predispose to injury. Our results suggest that acute laryngeal injury impacts functional recovery from critical illness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.