Evidence map›Paper›PMID 31634108›Full record

Trial reportThe Permanente journal2019

Lifestyle Interventions and Carotid Plaque Burden: A Comparative Analysis of Two Lifestyle Intervention Programs in Patients with Coronary Artery Disease.

Rachid A Elkoustaf, Omar M Aldaas, Colombus D Batiste, Adina Mercer, Mario Robinson, Darlene Newton, Raoul Burchett, Cynthia Cornelius, Heidi Patterson, Mohamed H Ismail

Open access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Permanente journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rachid A ElkoustafDepartment of Cardiology, Riverside Medical Center, CA.
Omar M AldaasDepartment of Medicine, University of California, San Diego, CA.
Colombus D BatisteDepartment of Cardiology, Riverside Medical Center, CA.
Adina MercerDepartment of Family Medicine, Riverside Medical Center, CA.
Mario RobinsonDepartment of Urology, Riverside Medical Center, CA.
Darlene NewtonDepartment of Preventive Medicine, Riverside Medical Center, CA.
Raoul BurchettDepartment of Preventive Medicine, Riverside Medical Center, CA.
Cynthia CorneliusDepartment of Radiology, Riverside Medical Center, CA.
Heidi PattersonDepartment of Cardiology, Riverside Medical Center, CA.
Mohamed H IsmailDepartment of Preventive Medicine, Riverside Medical Center, CA.
Riverside Regional Medical Center · USUniversity of California, San Diego · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cardioprotective effects of intensive lifestyle regimens in primary prevention have been elucidated; however, there is a paucity of data comparing the effects of different lifestyle regimens in patients with established coronary artery disease (CAD) or CAD equivalent, specifically vis-à-vis carotid plaque regression.

methodsWe performed a randomized, single-center, single-blind study in 120 patients with established CAD. Patients were randomly assigned to either 9 months of the Complete Health Improvement Program (CHIP), an outpatient lifestyle enrichment program that focuses on improving dietary choices, enhancing daily exercise, increasing support systems, and decreasing stress; or to 9 months of an ad hoc, nonsequential combination of various healthy living classes offered separately through a health maintenance organization and referred to as the Healthy Heart program. Baseline and 9-month change in carotid intima-media thickness (CIMT) were measured.

resultsAmong 120 participants, data were analyzed for 79, of which 68 (86%) completed the study. Both average CIMT and average maximum CIMT increased over 9 months, but the changes between groups were insignificant. There were marked differences in the mean body mass index favoring the CHIP group (-1.9 [standard deviation = 1.9]; p < 0.001) and statistically significant within-group improvements in blood pressure, triglyceride level, 6-minute walk test result, self-assessment well-being score, and Patient Health Questionnaire-9 score that were not observed between groups.

conclusionNeither the CHIP nor Healthy Heart was effective in inducing plaque regression in patients with established CAD after a 9-month period. However, both were effective in improving several CAD risk factors, which shows that the nonsequential offering of healthy lifestyle programs can lead to similar outcomes as a formal, sequential, established program (CHIP) in many aspects. These results have important implications as to how lifestyle changes will be implemented as tertiary prevention measures in the future.

Indexed as

Risk Reduction BehaviorAgedBlood PressureCarotid StenosisCoronary Artery DiseaseDietExerciseExercise TestFemaleHumansMalePlaque, AtheroscleroticSingle-Blind MethodStress, PsychologicalSurveys and QuestionnairesTriglyceridesTriglycerides

Identifiers

PMID31634108
PMCPMC6836566
OpenAlexW2988732352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.