Evidence map›Paper›PMID 31634048›Full record

ArticleHuman vaccines & immunotherapeutics2020

High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy.

Maddalena Grazzini, Giulio Arcangeli, Nicola Mucci, Paolo Bonanni, Costanza Bini, Angela Bechini, Sara Boccalini, Emilia Tiscione, Diana Paolini

Open access · bronzeAbstract read
In one paragraph

Article in Human vaccines & immunotherapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Observational
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Maddalena GrazziniDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-4094-4551
Giulio ArcangeliDepartment of Experimental and Clinical Medicine University of Florence, Florence, Italy.
Nicola MucciDepartment of Experimental and Clinical Medicine University of Florence, Florence, Italy.
Paolo BonanniDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0003-2875-3744
Costanza BiniDepartment of Experimental and Clinical Medicine University of Florence, Florence, Italy.
Angela BechiniDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0002-6013-8779
Sara BoccaliniDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0002-9695-7549
Emilia TiscioneDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0002-9279-5431
Diana PaoliniDepartment of Health Sciences, University of Florence, Florence, Italy.ORCID 0000-0001-8062-5710
University of Florence · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Healthcare workers (HCWs) are considered high-risk subjects for Hepatitis B Virus (HBV) infection due to occupational exposure to blood and body fluids. Vaccination represents the core strategy for HBV infection prevention. Following our previous publication on this topic, we aimed to assess the effectiveness of booster vaccine doses in eliciting the immunological response in seronegative (<10 mIU/mL) HCWs and students of Careggi Teaching Hospital, Florence (Italy). All subjects received primary vaccination course, and they were tested for serum anti-HBs antibodies. In seronegative subjects, a challenge dose of vaccine was administered and the test was repeated 1 month later. Six hundred and ninety-eight (87.8%) of 795 HCWs and students tested responded to the challenge dose. After this challenge dose, males more often had negative anti-HBs titer compared with females (15.9% vs 10.2%;

Indexed as

Hepatitis BHepatitis B VaccinesDelivery of Health CareFemaleHepatitis B AntibodiesHepatitis B Surface AntigensHumansImmunization, SecondaryItalyMaleStudentsVaccinationHepatitis B AntibodiesHepatitis B Surface AntigensHepatitis B Vaccinesboosterhealth care workersHepatitis Bimmunological responseseroconversionvaccination

Identifiers

PMID31634048
PMCPMC7227660
OpenAlexW2981703209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.