Evidence map›Paper›PMID 31633879›Full record

ArticleInternational forum of allergy & rhinology2019

Mometasone absorption in cultured airway epithelium.

Tuong T Nguyen, Paul S Soma, Teresa Mascenik, Catherine A Lewis, Rhianna E Lee, Brian D Thorp, Adam M Zanation, Charles S Ebert, Brent A Senior, Scott H Randell and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International forum of allergy & rhinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Tuong T NguyenMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Paul S SomaDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Teresa MascenikMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Catherine A LewisMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Rhianna E LeeMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Brian D ThorpDepartment of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Adam M ZanationDepartment of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Charles S EbertDepartment of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Brent A SeniorDepartment of Otolaryngology-Head & Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Scott H RandellMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Brandie M EhrmannDepartment of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Adam J KimpleMarsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC.ORCID 0000-0003-1670-8401
University of North Carolina at Chapel Hill · US

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Martina Gentzsch · 2004 to 2026
$26.5M
North Carolina Translational and Clinical Science Institute (NC TraCS) KL2KL2TR002490 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WEINBERGER, MORRIS · 2018 to 2022
$11.0M
NCATS NIH HHS KL2 TR002490NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

backgroundTopical mometasone is frequently used as an intranasal spray, on drug-eluting stents, and compounded by specialty pharmacies as a sinus rinse. A typical sinus rinse contains 1.2 mg of mometasone dissolved in 240 mL of buffered saline and is flushed through the sinonasal cavity. The mometasone irrigation rapidly flows to the contralateral sinonasal cavity or the nasopharynx with a contact time on the order of 5 to 10 seconds. However, no information is available on the absorption rate of topical mometasone on the sinonasal surface.

methodsTo determine the absorption characteristics of mometasone, we harvested nasal epithelium from 2 healthy donors and differentiated them into a mature ciliated epithelium on Millicell membranes. We applied mometasone to the apical surface for various time intervals and then rinsed off non-absorbed mometasone with phosphate-buffered saline. Millicell membranes with the adherent epithelial cells were then harvested and stored in guanidine hydrochloride for quantification using high-performance liquid chromatography-mass spectrometry.

resultsFifty percent of the maximal absorption occurred after an average of 38 minutes after application, and maximal absorption occurred after an average of 114 minutes.

conclusionOur data provide an estimate for rates of absorption of mometasone applied to the sinonasal cavity and suggest that the absorption rates poorly match contact time during saline lavage.

Indexed as

Administration, IntranasalAnti-Allergic AgentsAnti-Inflammatory AgentsCells, CulturedHumansMometasone FuroateNasal MucosaAnti-Allergic AgentsAnti-Inflammatory AgentsMometasone Furoateallergic rhinitisintranasal corticosteroidsnasal irrigationssteroid rinses

Identifiers

PMID31633879
PMCPMC6927533
OpenAlexW2981615363

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.