Evidence map›Paper›PMID 31633840›Full record

ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2020

Integrin Antibody Decreases Deformability of Patient-Derived Pre-B Acute Lymphocytic Leukemia Cells as Measured by High-Frequency Acoustic Tweezers.

Hsiao-Chuan Liu, Eun Ji Gang, Hye Na Kim, Nour Abdel-Azim, Ruimin Chen, Hisham Abdel-Azim, K Kirk Shung, Yong-Mi Kim

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Manipulation and Mechanical Deformation of Leukemia Cells by High-Frequency Ultrasound Single Beam.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hsiao-Chuan LiuDepartment of Biomedical Engineering and National Institutes of Health Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-5410-8821
Eun Ji GangDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Hye Na KimDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Nour Abdel-AzimDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Ruimin ChenDepartment of Biomedical Engineering and National Institutes of Health Ultrasonic Transducer Resource Center, University of Southern California, Los Angeles, California, USA.
Hisham Abdel-AzimDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
K Kirk ShungDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
Yong-Mi KimDepartment of Pediatrics, Division of Hematology, Oncology, Blood, and Marrow Transplantation, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California, USA.
University of Southern California · US

Funding

Understanding the niche of minimal residual disease leukemia cellsR01CA172896 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI KIM, YONG-MI · 2013 to 2022
$3.7M
NCI NIH HHS R01 CA172896NIH HHS R01-CA172896
6 · The paper itself

Abstract

objectivesThis article reports a study of cell mechanics in patient-derived (primary) B-cell acute lymphocytic leukemia (ALL) cells treated with antibodies against integrins. Leukemia cell adhesion to stromal cells mediates chemotherapeutic drug resistance, also known as cell adhesion-mediated chemotherapeutic drug resistance. We have previously shown that antibodies against integrin α

methodsIn this study, the deformability of primary pre-B ALL cells was evaluated by single-beam acoustic tweezers after treatments with the de-adhering antibody Tysabri or P5G10 against integrin α

resultsWe demonstrated that primary ALL cells treated with P5G10 expressed decreased deformability compared with immunoglobulin G

conclusionsThese results suggest that decreased deformability is associated with an integrin α

Indexed as

AcousticsCell AdhesionCells, CulturedHumansImmunoglobulin GImmunologic FactorsIntegrinsNatalizumabPrecursor Cell Lymphoblastic Leukemia-LymphomaUltrasonographyImmunoglobulin GImmunologic FactorsIntegrinsNatalizumabacoustic tweezersacute lymphoblastic leukemiaantibodydeformabilitydrug resistanceintegrins

Identifiers

PMID31633840
PMCPMC7493593
OpenAlexW2982266803

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.