ArticleBritish journal of clinical pharmacology2020
Preventable adverse drug events: Descriptive epidemiology.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Trial
- When does Follow-up on Adverse Events Improve the Understanding of Medicine and Vaccine Safety? Insights from Global Expert Perspectives.Drug safety · 2026Article
- Adverse events as key risk factors for in-hospital mortality in intensive care units.Critical care (London, England) · 2026Observational
- Clinical and Economic Impact of Expanded TPMT Testing to Prevent Thiopurine-Induced Myelosuppression in Australia: A Budget Impact Analysis.Clinical and translational science · 2026Article
- Model-Informed Precision Dosing: Conceptual Framework for Therapeutic Drug Monitoring Integrating Machine Learning and Artificial Intelligence Within Population Health Informatics.Journal of personalized medicine · 2026Review
- Article
- Retrospective Analysis of Adverse Drug Reactions in Patients with Type 2 Diabetes Mellitus and Development of a Risk Prediction Model.International journal of general medicine · 2026Article
- Mechanistic insights into human carboxylesterase 2 (CES2) inhibition by the CES1 prodrug substrate remdesivir.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- Barriers and enablers of adverse drug event reporting in South Africa: a cross-sectional survey of medicine users.BMC public health · 2025Article
- Developing a SNOMED CT-Based Value Set to Document Symptoms and Diagnoses for Adverse Drug Events: Mixed Methods Study.JMIR medical informatics · 2025Article
- Risk Management of Medication Errors: Improving the Quality of Pharmacotherapeutic Practice.Pharmacology research & perspectives · 2025Article
- Medication-related hospitalisations in patients with SLE.Lupus science & medicine · 2025Article
- Potential inappropriate medications and drug-drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database.Frontiers in pharmacology · 2025Article
- Potential Adverse Drug Events Identified with Decision Support Algorithms from Janusmed Risk Profile-A Retrospective Population-Based Study in a Swedish Region.Pharmacy (Basel, Switzerland) · 2024Article
- Evaluation of medication safety assessment tools for pharmacist-led medication reviews: the Eastern European pilot project.Frontiers in pharmacology · 2024Article
- Sharing Adverse Drug Event Reports Between Hospitals and Community Pharmacists to Inform Re-dispensing: An Analysis of Reports and Process Outcomes.Drug safety · 2023Observational
- Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms.Journal of clinical medicine · 2023Article
- Evaluation of patient safety culture in community pharmacies.Exploratory research in clinical and social pharmacy · 2023Article
- Article
- Preventable adverse drug events causing hospitalisation: identifying root causes and developing a surveillance and learning system at an urban community hospital, a cross-sectional observational study.BMJ open quality · 2021Observational
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimOur objective was to identify preventable adverse drug events and factors contributing to their development.
methodsWe performed a retrospective chart review combining data from three prospective multicentre observational studies that assessed emergency department patients for adverse drug events. A clinical pharmacist and physician independently reviewed the charts, extracted data and rated the preventability of each adverse drug event. A third reviewer adjudicated all discordant or uncertain cases. We calculated the proportion of adverse drug events that were deemed preventable, performed multivariable logistic regression to explore the characteristics of patients with preventable events, and identified contributing factors.
resultsWe reviewed the records of 1 356 adverse drug events in 1 234 patients. Raters considered 869 (64.1%) of adverse drug events probably or definitely preventable. Patients with mental health diagnoses (OR 1.8; 95% CI 1.3-2.5) and diabetes (OR 1.7; 95% CI 1.2-2.4) were more likely to present with preventable events. The medications most commonly implicated in preventable events were warfarin (9.4%), hydrochlorothiazide (4.5%), furosemide (4.0%), insulin (3.9%) and acetylsalicylic acid (2.7%). Common contributing factors included inadequate patient instructions, monitoring and follow-up, and reassessments after medication changes had been made.
conclusionsOur study suggests that patients with mental health conditions and diabetes require close monitoring. Efforts to address the identified contributing factors are needed.
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