ArticleInvestigative radiology2019
Low-Radiation-Dose Stress Myocardial Perfusion Measurement Using First-Pass Analysis Dynamic Computed Tomography: A Preliminary Investigation in a Swine Model.
Article in Investigative radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model.European radiology experimental · 2024Article
- Low-dose quantitative CT myocardial flow measurement using a single volume scan: phantom and animal validation.Journal of medical imaging (Bellingham, Wash.) · 2023Article
- Evaluation and timing optimization of CT perfusion first pass analysis in comparison to maximum slope model in pancreatic adenocarcinoma.Scientific reports · 2023Article
- Metabolic flux between organs measured by arteriovenous metabolite gradients.Experimental & molecular medicine · 2022Review
- Dynamic CT myocardial perfusion without image registration.Scientific reports · 2022Article
- Absolute cerebral blood flow: Assessment with a novel low-radiation-dose dynamic CT perfusion technique in a swine model.Journal of neuroradiology = Journal de neuroradiologie · 2022Article
- Combining perfusion and angiography with a low-dose cardiac CT technique: a preliminary investigation in a swine model.The international journal of cardiovascular imaging · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesThe aim of this study was to assess the feasibility of a prospective first-pass analysis (FPA) dynamic computed tomography (CT) perfusion technique for accurate low-radiation-dose global stress perfusion measurement. MATERIALS AND
methodsThe prospective FPA technique was evaluated in 10 swine (42 ± 12 kg) by direct comparison to a previously validated retrospective FPA technique. Of the 10 swine, 3 had intermediate stenoses with fractional flow reserve severities of 0.70 to 0.90. In each swine, contrast and saline were injected peripherally followed by dynamic volume scanning with a 320-slice CT scanner. Specifically, for the reference standard retrospective FPA technique, volume scans were acquired continuously at 100 kVp and 200 mA over 15 to 20 seconds, followed by systematic selection of only 2 volume scans for global perfusion measurement. For the prospective FPA technique, only 2 volume scans were acquired at 100 kVp and 50 mA for global perfusion measurement. All prospective global stress perfusion measurements were then compared with the corresponding reference standard retrospective global stress perfusion measurements through regression analysis. The CTDIvol and size-specific dose estimate of the prospective FPA technique were also determined.
resultsAll prospective global stress perfusion measurements (PPRO) at 50 mA were in good agreement with the reference standard retrospective global stress perfusion measurements (PREF) at 200 mA (PPRO = 1.07 PREF -0.09, r = 0.94; root-mean-square error = 0.30 mL/min per gram). The CTDIvol and size-specific dose estimate of the prospective FPA technique were 2.3 and 3.7 mGy, respectively.
conclusionsAccurate low-radiation-dose global stress perfusion measurement is feasible using a prospective FPA dynamic CT perfusion technique.
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