Evidence map›Paper›PMID 31633385›Full record

ArticleAdvances in dental research2019

Oral Rehabilitation of Patients Sustaining Orofacial Injuries: The UPenn Initiative.

Q Z Zhang, C Chen, M B Chang, R M Shanti, S B Cannady, B W O'Malley, S Shi, A D Le

Abstract read
In one paragraph

Article in Advances in dental research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Advances in Precision Oral Health Research.Advances in dental research · 2019
    Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Q Z ZhangDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
C ChenDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
M B ChangDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
R M ShantiDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
S B CannadyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
B W O'MalleyDepartment of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
S ShiDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.
A D LeDepartment of Oral & Maxillofacial Surgery & Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA, USA.

Funding

FAS Controls Exosome-Mediated miRNA Transfer in MSC-Based TherapyR00DE025915 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHI-DER · 2019 to 2021
$732k
Epigenetic Regulation of Mesenchymal Stem Cell Transplantation in AgingR03DE028026 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHI-DER · 2019 to 2020
$324k
FAS Controls Exosome-Mediated miRNA Transfer in MSC-Based TherapyK99DE025915 · NIDCR · UNIVERSITY OF PENNSYLVANIA · PI CHEN, CHI-DER · 2016 to 2017
$142k
NIDCR NIH HHS K99 DE025915NIDCR NIH HHS R00 DE025915NIDCR NIH HHS R03 DE028026
6 · The paper itself

Abstract

Tissue injuries in the oral and maxillofacial structures secondary to trauma, warfare, ablative cancer, and benign tumor surgery result in significant losses of speech, masticatory and swallowing functions, aesthetic deformities, and overall psychological stressors and compromise. Optimal oral rehabilitation remains a formidable challenge and an unmet clinical need due to the influence of multiple factors related to the physiologic limitations of tissue repair, the lack of site and function-specific donor tissues and constructs, and an integrated team of multidisciplinary professionals. The advancements in stem cell biology, biomaterial science, and tissue engineering technologies, particularly the 3-dimensional bioprinting technology, together with digital imaging and computer-aided design and manufacturing technologies, have paved the path for personalized/precision regenerative medicine. At the University of Pennsylvania, we have launched the initiative to integrate multidisciplinary health professionals and translational/clinical scientists in medicine, dentistry, stem cell biology, tissue engineering, and regenerative medicine to develop a comprehensive, patient-centered approach for precision and personalized reconstruction, as well as oral rehabilitation of patients sustaining orofacial tissue injuries and defects, especially oral cancer patients.

Indexed as

BioprintingMouthPrinting, Three-DimensionalTissue EngineeringEsthetics, DentalHumansRegenerative Medicine3D printingpersonalized/precision medicinereconstructionregenerative medicinestem cell(s)tissue engineering

Identifiers

PMID31633385
PMCPMC6806127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.