ArticleJournal of cellular and molecular medicine2019
The roles of circRFWD2 and circINO80 during NELL-1-induced osteogenesis.
Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- NELL-1: role and mechanisms in disease pathogenesis and development.Frontiers in cell and developmental biology · 2026Review
- Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review).International journal of molecular medicine · 2025Review
- Circ_0003764 Regulates the Osteogenic Differentiation of Periodontal Ligament Stem Cells.International dental journal · 2024Article
- Regulatory mechanisms of circular RNAs during human mesenchymal stem cell osteogenic differentiation.Theranostics · 2024Review
- Emerging roles of circular RNAs in stem cells.Genes & diseases · 2023Review
- Circular RNAs: Promising Targets in Osteoporosis.Current osteoporosis reports · 2023Review
- Runx2 and Nell-1 in dental follicle progenitor cells regulate bone remodeling and tooth eruption.Stem cell research & therapy · 2022Review
- circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis.International journal of oral science · 2022Article
- Signaling network regulating osteogenesis in mesenchymal stem cells.Journal of cell communication and signaling · 2022Review
- Circular RNAs in stem cells: from basic research to clinical implications.Bioscience reports · 2022Review
- Exercise for osteoporosis: A literature review of pathology and mechanism.Frontiers in immunology · 2022Review
- Reconstruction and analysis of the aberrant lncRNA-miRNA-mRNA network based on competitive endogenous RNA in adenoid cystic carcinoma of the salivary gland.Translational cancer research · 2021Article
- METTL3-Mediated lncRNA mStem cell reviews and reports · 2021Article
- Functions and mechanisms of circular RNAs in regulating stem cell differentiation.RNA biology · 2021Review
- NELL-1 Increased the Osteogenic Differentiation and mRNA Expression of Spheroids Composed of Stem Cells.Medicina (Kaunas, Lithuania) · 2021Article
- circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206/CX43 axis.Stem cell research & therapy · 2020Article
- Role of LncRNAs and CircRNAs in Bone Metabolism and Osteoporosis.Frontiers in genetics · 2020Review
- Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis.Theranostics · 2020Article
- The roles of circRFWD2 and circINO80 during NELL-1-induced osteogenesis.Journal of cellular and molecular medicine · 2019Article
- CircRFWD2 Promotes Osteogenic Differentiation of human Dental Pulp Stem Cells by Targeting miR-6817-5p Through BMP-Smad and p38 MAPK Pathway.Cell transplantationArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone defects caused heavy social and economic burdens worldwide. Nel-like molecule, type 1 (NELL-1) could enhance the osteogenesis and the repairment of bone defects, while the specific mechanism remains to be elucidated. Circular RNAs (circRNAs) have been found to play critical roles in the tissue development and serve as biomarkers for various diseases. However, it remains unclear that the expression patterns of circRNAs and the roles of them played in recombinant NELL-1-induced osteogenesis of human adipose-derived stem cells (hASCs). In this study, we performed RNA-sequencing to investigate the expression profiles of circRNAs in recombinant NELL-1-induced osteogenic differentiation and identified two key circRNAs, namely circRFWD2 and circINO80. These two circRNAs were confirmed to be up-regulated during recombinant NELL-1-induced osteogenesis, and knockdown of them affected the positive effect of NELL-1 on osteogenesis. CircRFWD2 and circINO80 could interact with hsa-miR-6817-5p, which could inhibit the osteogenesis. Silencing hsa-miR-6817-5p could partially reverse the negative effect of si-circRFWD2 and si-circINO80 on the osteogenesis. Therefore, circRFWD2 and circINO80 could regulate the expression of hsa-miR-6817-5p and influence the recombinant NELL-1-induced osteogenic differentiation of hASCs. It opens a new window to better understanding the effects of NELL-1 on the osteogenic differentiation of hASCs and provides potential molecular targets and novel methods for bone regeneration efficiently and safely.
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