Evidence map›Paper›PMID 31633082›Full record

ArticleEpigenetics insights2019

Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites.

Todd Lenz, Karine G Le Roch

Open access · hybridAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenetics insights, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Frontiers in microbiology · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Todd LenzDepartment of Molecular, Cell and Systems Biology (MCSB), University of California, Riverside, Riverside, CA, USA.
Karine G Le RochDepartment of Molecular, Cell and Systems Biology (MCSB), University of California, Riverside, Riverside, CA, USA.ORCID https://orcid.org/0000-0002-4862-9292
University of California, Riverside · US

Funding

Chromatin structure and control of gene expression in the human malaria parasiteR01AI136511 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2018 to 2022
$3.4M
Evolution of the 3D chromatin structure in apicomplexan parasitesR21AI142506 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI LE ROCH, KARINE GAELLE · 2019 to 2020
$479k
Medical Research Council MR/K011782/1NIAID NIH HHS R01 AI136511NIAID NIH HHS R21 AI142506
6 · The paper itself

Abstract

Mounting evidence supports the idea that epigenetic, and the overall 3-dimensional (3D) architecture of the genome, plays an important role in gene expression for eukaryotic organisms. We recently used Hi-C methodologies to generate and compare the 3D genome of 7 different apicomplexan parasites, including several pathogenic and less pathogenic malaria parasites as well as related human parasites

Indexed as

antigenic variationBabesiagenome organizationHi-CmalariaPlasmodiumSICAvarToxoplasmavarvirulence

Identifiers

PMID31633082
PMCPMC6769224
OpenAlexW2977968370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.