ArticleCommunications biology2019
An improved neuroanatomical model of the default-mode network reconciles previous neuroimaging and neuropathological findings.
Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 7 of them syntheses that pooled it.
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181 citing papers in PubMed, 7 syntheses or guidelines pooled it, 368 citations in OpenAlex.
- Topography and functional connectivity analysis of heart surgery-associated brain lesions: a literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Resting-state functional connectivity alterations in dementia with Lewy bodies: a systematic review and activation likelihood estimation meta-analysis.Brain imaging and behavior · 2026Pooled it
- The convergent neuroscience of Christian prayer and attachment relationships in the context of mental health: a systematic review.Frontiers in psychology · 2025Pooled it
- Neuroanatomical and clinical correlates of prodromal dementia with Lewy bodies: a systematic literature review of neuroimaging findings.Journal of neurology · 2024Pooled it
- White matter microstructure in children and adolescents with ADHD.NeuroImage. Clinical · 2022Pooled it
- Anchoring the human olfactory system within a functional gradient.NeuroImage · 2020Pooled it
- Obesity is associated with reduced orbitofrontal cortex volume: A coordinate-based meta-analysis.NeuroImage. Clinical · 2020Pooled it
- Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression.Molecular psychiatry · 2025Trial
- Longitudinal changes in functional connectivity and pain-induced brain activations in patients with migraine: a functional MRI study pre- and post- treatment with Erenumab.The journal of headache and pain · 2022Trial
- Effect of short-term, high-dose probiotic supplementation on cognition, related brain functions and BDNF in patients with depression: a secondary analysis of a randomized controlled trial.Journal of psychiatry & neuroscience : JPNTrial
- Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome.Biological psychiatry global open science · 2026Article
- Negative BOLD response to interictal discharges in epilepsy using intracranial EEG-fMRI.Neuroimage. Reports · 2026Article
- The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer's disease.Nature communications · 2026Article
- Effects of electroconvulsive therapy on cerebellar-cerebral functional connectivity in patients with treatment-resistant depression and their correlations with gene expression profiles.Psychiatry and clinical neurosciences · 2026Article
- Creativity: a (white) matter of connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Thalamocortical orchestration of human theory of mind.bioRxiv : the preprint server for biology · 2026Article
- Resting-State Cortical Network and Subcortical Hyperconnectivity in Youth With Generalized Anxiety Disorder in the ABCD Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Article
- Distinct and shared neurobiological patterns in PTSD and CPTSD: evidence from resting-state fMRI.BMC psychiatry · 2026Article
- High-resolution electrophysiological mapping of effective connectivity of lateral prefrontal cortex.Brain : a journal of neurology · 2026Article
121 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is constituted of multiple networks of functionally correlated brain areas, out of which the default-mode network (DMN) is the largest. Most existing research into the DMN has taken a corticocentric approach. Despite its resemblance with the unitary model of the limbic system, the contribution of subcortical structures to the DMN may be underappreciated. Here, we propose a more comprehensive neuroanatomical model of the DMN including subcortical structures such as the basal forebrain, cholinergic nuclei, anterior and mediodorsal thalamic nuclei. Additionally, tractography of diffusion-weighted imaging was employed to explore the structural connectivity, which revealed that the thalamus and basal forebrain are of central importance for the functioning of the DMN. The contribution of these neurochemically diverse brain nuclei reconciles previous neuroimaging with neuropathological findings in diseased brains and offers the potential for identifying a conserved homologue of the DMN in other mammalian species.
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