ArticleScience advances2019
Morphology and composition play distinct and complementary roles in the tolerance of plantar skin to mechanical load.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Keratin 9 regulates mechanosensitive YAP1 signalling in palmoplantar epidermis.Nature cell biology · 2026Article
- Biomechanics of Human Plantar Skin: Experimental and Constitutive Analysis.Annals of biomedical engineering · 2026Article
- Correlative Multimodal Framework Reveals Supramolecular Chirality Loss Preceding Fibrillar Rarefaction in Dermal Collagen.ACS nano · 2026Article
- GJB6 missense variant in a Labrador Retriever with paw pad hyperkeratosis.Animal genetics · 2026Article
- Article
- Ultrasonographic Analysis of Site-Specific Plantar Skin Thickness for Melanoma Staging and Excision.Clinical anatomy (New York, N.Y.) · 2026Article
- Atomic force microscope protocols for characterising the elastoviscoplastic biomechanical properties of corneocytes.Communications biology · 2025Article
- Article
- A Cross-Sectional Study Exploring the Suitability of Skin Hydration Measurement Devices for Use on the Foot.Journal of foot and ankle research · 2025Article
- Nonlinear Optical Response in Layer-Stacked Gallenene with Ferroelectric Polarization.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Trophic Ulcer Elimination in Free Flap Reconstructed Weight-Bearing Plantar Defect: A Clinical Challenge.Seminars in plastic surgery · 2025Review
- Materials and Structures Inspired by Human Heel Pads for Advanced Biomechanical Function.Biomimetics (Basel, Switzerland) · 2025Review
- Second harmonic generation imaging reveals entanglement of collagen fibers in the elephant trunk skin dermis.Communications biology · 2025Article
- Skin adaptation in lower limb amputees assessed through Raman spectroscopy and mechanical characterization.Journal of the Royal Society, Interface · 2025Article
- Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery.Pharmaceutics · 2024Review
- Applying the Atomic Force Microscopy Technique in Medical Sciences-A Narrative Review.Biomedicines · 2024Review
- Structural and molecular characteristics of weight-bearing volar skin can be reconstituted by micro skin tissue column grafting.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Immediate but Temporal Response: The Role of Distal Epithelial Cells in Wound Healing.Stem cell reviews and reports · 2024Article
- The role of interface geometry and appendages on the mesoscale mechanics of the skin.Biomechanics and modeling in mechanobiology · 2024Article
- A Year at the Forefront of Hydrostat Motion.Biology open · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Plantar skin on the soles of the feet has a distinct morphology and composition that is thought to enhance its tolerance to mechanical loads, although the individual contributions of morphology and composition have never been quantified. Here, we combine multiscale mechanical testing and computational models of load bearing to quantify the mechanical environment of both plantar and nonplantar skin under load. We find that morphology and composition play distinct and complementary roles in plantar skin's load tolerance. More specifically, the thick stratum corneum provides protection from stress-based injuries such as skin tears and blisters, while epidermal and dermal compositions provide protection from deformation-based injuries such as pressure ulcers. This work provides insights into the roles of skin morphology and composition more generally and will inform the design of engineered skin substitutes as well as the etiology of skin injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.