ArticleScience advances2019
Synchronization of stochastic expressions drives the clustering of functionally related genes.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Evolutionary tuning of a biosynthetic gene cluster drives furanocoumarin accumulation and diversification.Nature communications · 2026Article
- Contrasting selective signatures of gene expression plasticity in response to antifungal clotrimazole and common environmental stresses in yeast.Nature communications · 2026Article
- The transcriptional coordination of functional gene clusters is dependent on multiple chromatin remodelers in a haploid strain of the budding yeast,Frontiers in fungal biology · 2025Article
- Plasticity and environment-specific relationships between gene expression and fitness in Saccharomyces cerevisiae.Nature ecology & evolution · 2024Article
- Article
- What Has Genomics Taught An Evolutionary Biologist?Genomics, proteomics & bioinformatics · 2023Review
- Regulatory mechanisms ensuring coordinated expression of functionally related genes.Trends in genetics : TIG · 2022Review
- The evolution of the GALactose utilization pathway in budding yeasts.Trends in genetics : TIG · 2022Review
- Genomic reconfiguration in parasitic plants involves considerable gene losses alongside global genome size inflation and gene births.Plant physiology · 2021Article
- Prioritizing and characterizing functionally relevant genes across human tissues.PLoS computational biology · 2021Article
- Systematic Analysis of Functionally Related Gene Clusters in the Opportunistic Pathogen,Microorganisms · 2021Article
- Genomic Considerations for the Modification ofMicroorganisms · 2020Review
- Allele-specific single-cell RNA sequencing reveals different architectures of intrinsic and extrinsic gene expression noises.Nucleic acids research · 2020Article
- Genomic clustering within functionally related gene families inComputational and structural biotechnology journal · 2020Review
- Synchronized replication of genes encoding the same protein complex in fast-proliferating cells.Genome research · 2019Article
- Chromosome-wide co-fluctuation of stochastic gene expression in mammalian cells.PLoS genetics · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Functionally related genes tend to be chromosomally clustered in eukaryotic genomes even after the exclusion of tandem duplicates, but the biological significance of this widespread phenomenon is unclear. We propose that stochastic expression fluctuations of neighboring genes resulting from chromatin dynamics are more or less synchronized such that their expression ratio is more stable than that for unlinked genes. Consequently, chromosomal clustering could be advantageous when the expression ratio of the clustered genes needs to stay constant, for example, because of the accumulation of toxic compounds when this ratio is altered. Evidence from manipulative experiments on the yeast
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