ArticleScience advances2019
Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
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Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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51citing papers in PubMed
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51 citing papers in PubMed, 109 citations in OpenAlex.
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- Molecular insights into ligand recognition and signaling of OXGR1.Nature communications · 2025Article
- Molecular insights into ago-allosteric modulation at cysteinyl leukotriene receptor 2.Nature communications · 2025Article
- Structures of G-protein coupled receptor HCAR3 in complex with selective agonists reveal the basis for ligand recognition and selectivity.PLoS biology · 2025Article
- Structural insights into the mechanism of activation and inhibition of the prostaglandin D2 receptor 1.Nature communications · 2025Article
- A conserved mechanism of LRRC8 channel inhibition by two structurally distinct drugs.Communications biology · 2025Article
- New insights on pharmacological potential of montelukast: a comprehensive review.Inflammopharmacology · 2025Review
- Evaluation of Small-Molecule Binding Site Prediction Methods on Membrane-Embedded Protein Interfaces.Journal of chemical information and modeling · 2025Article
- Unlocking GPCR-ligand interactions: Measuring binding affinities with thermal shift assay.Protein science : a publication of the Protein Society · 2025Article
- Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Structure-guided design of partial agonists at an opioid receptor.Nature communications · 2025Article
- Structural basis for lipid-mediated activation of G protein-coupled receptor GPR55.Nature communications · 2025Article
- Cryo-EM structure of an activated GPR4-Gs signaling complex.Nature communications · 2025Article
- Structural elucidation of Langat virus helicase unveils dual-target inhibition for broad-spectrum anti-flaviviruses strategy.Frontiers in cellular and infection microbiology · 2025Article
- Article
- Prediction of the binding interactions between rosmarinic acid and cysteinyl leukotriene receptor type 1 by molecular docking and immobilized receptor chromatography.RSC advances · 2024Article
- Structure-Guided Design of Partial Agonists at an Opioid Receptor.Research square · 2024Article
- G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024Article
- Structural biology in the age of X-ray free-electron lasers and exascale computing.Current opinion in structural biology · 2024Review
- Evaluation ofMolecules (Basel, Switzerland) · 2024Article
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Authors and funding
26 authors at 6 institutions in 6 countries.
Aleksandra LugininaResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0003-2697-456X
Anastasiia GusachResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0002-2594-8573
Egor MarinResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0003-2369-1732
Alexey MishinResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0003-3759-380X
Rebecca BrouilletteDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.ORCID 0000-0002-5466-9653
Petr PopovResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Anna ShiriaevaDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
Élie Besserer-OffroyDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.ORCID 0000-0002-7473-7043
Jean-Michel LongpréDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.ORCID 0000-0003-3985-2318
Elizaveta LyapinaResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0003-0719-8497
Andrii IshchenkoDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.
Nilkanth PatelDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-9856-3041
Vitaly PolovinkinInstitute of Complex Systems, ICS-6: Structural Biochemistry, Research Centre Juelich, Juelich, Germany.ORCID 0000-0002-3630-5565
Nadezhda SafronovaResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0002-7770-0174
Andrey BogorodskiyResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Evelina EdelweissInstitut de Biologie Structurale J.-P. Ebel, Université Grenoble Alpes-CEA-CNRS, Grenoble 38000, France.
Hao HuDepartment of Physics, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0003-3472-0404
Uwe WeierstallDepartment of Physics, Arizona State University, Tempe, AZ 85287, USA.ORCID 0000-0002-3594-930X
Wei LiuBiodesign Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Alexander BatyukLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA.ORCID 0000-0002-9393-2880
Valentin GordeliyResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
Gye Won HanDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-4107-835X
Philippe SarretDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Quebec J1H 5N4, Canada.ORCID 0000-0002-7627-701X
Vsevolod KatritchDepartments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-3883-4505
Valentin BorshchevskiyResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0003-4398-9712
Vadim CherezovResearch Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.ORCID 0000-0002-5265-3914
Moscow Institute of Physics and Technology · RUUniversity of Southern California · USUniversité de Sherbrooke · CAArizona State University · USCentre National de la Recherche Scientifique · FRSLAC National Accelerator Laboratory · US
Funding
Structural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6MStructure Determination of G Protein-Coupled Receptors by Microcrystal Electron DiffractionR01GM124152 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NANNENGA, BRENT · 2017 to 2021
$1.6MStructure and Function of Dopamine ReceptorsR21DA042298 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIU, WEI · 2017 to 2018
$404kNIDA NIH HHS R21 DA042298NIGMS NIH HHS R01 GM124152NIGMS NIH HHS R35 GM127086
Abstract
The G protein-coupled cysteinyl leukotriene receptor CysLT
Indexed as
Anti-Asthmatic AgentsBinding SitesChromonesCrystallography, X-RayHumansIndolesLeukotriene AntagonistsLigandsMolecular Docking SimulationPhenylcarbamatesProtein Structure, TertiaryReceptors, LeukotrieneRecombinant ProteinsSodiumSulfonamidesTosyl CompoundsAnti-Asthmatic AgentsChromonesIndolesLeukotriene Antagonistsleukotriene D4 receptorLigandsPhenylcarbamatespranlukastReceptors, LeukotrieneRecombinant ProteinsSodiumSulfonamidesTosyl Compoundszafirlukast
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