ArticleScience advances2019
Habenular and striatal activity during performance feedback are differentially linked with state-like and trait-like aspects of tobacco use disorder.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Meta-analytic clustering dissociates brain activity and behavior profiles across reward processing paradigms.Cognitive, affective & behavioral neuroscience · 2020Pooled it
- Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Trial
- Short-term nicotine deprivation alters dorsal anterior cingulate glutamate concentration and concomitant cingulate-cortical functional connectivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Striatal Prediction Error Tracking Moderates the Influence of Social Exposure on Adolescent Substance Use Curiosity.Human brain mapping · 2026Article
- Habenula-ventral tegmental area functional coupling and risk aversion in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Changes in distinct brain systems identified with fMRI during smoking cessation treatment with varenicline: a review.Psychopharmacology · 2024Review
- Development and validation of dependence and craving measures specific to athletes who use anabolic-androgenic steroids.Frontiers in psychology · 2024Article
- Altered dynamic functional connectivity of insular subdivisions among male cigarette smokers.Frontiers in psychiatry · 2024Article
- Developmental Changes in Habenular and Striatal Social Reinforcement Responsivity Across Adolescence Linked With Substance Use.Biological psychiatry · 2023Article
- Nicotine addiction: More than just dopamine.Current opinion in neurobiology · 2023Review
- Addictive brain-network identification by spatial attention recurrent network with feature selection.Brain informatics · 2023Article
- Risky decision-making strategies mediate the relationship between amygdala activity and real-world financial savings among individuals from lower income households: A pilot study.Behavioural brain research · 2022Article
- Neurobiological Mechanisms of Nicotine Reward and Aversion.Pharmacological reviews · 2022Review
- Avoiding monetary loss: A human habenula functional MRI ultra-high field study.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Reversal of Functional Brain Activity Related to Gut Microbiome and Hormones After VSG Surgery in Patients With Obesity.The Journal of clinical endocrinology and metabolism · 2021Observational
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
The habenula, an epithalamic nucleus involved in reward and aversive processing, may contribute to negative reinforcement mechanisms maintaining nicotine use. We used a performance feedback task that differentially activates the striatum and habenula and administered nicotine and varenicline (versus placebos) to overnight-abstinent smokers and nonsmokers to delineate feedback-related functional brain alterations both as a function of smoking trait (smokers versus nonsmokers) and drug administration state (drug versus placebo). Smokers showed less striatal responsivity to positive feedback, an alteration not mitigated by drug administration, but rather correlated with trait-level addiction severity. Conversely, nicotine administration reduced habenula activity following both positive and negative feedback among abstinent smokers, but not nonsmokers, and increased habenula activity among smokers correlated with elevated state-level tobacco cravings. These outcomes highlight a dissociation between neurobiological processes linked with the dependence severity trait and the nicotine withdrawal state. Interventions simultaneously targeting both aspects may improve currently poor cessation outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.